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rs2066853

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0
Make rs2066853(A;A)
Make rs2066853(A;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position17339486
GeneAHR
is asnp
is mentioned by
dbSNPrs2066853
ebirs2066853
HLIrs2066853
Exacrs2066853
Varsomers2066853
Maprs2066853
PheGenIrs2066853
hapmaprs2066853
1000 genomesrs2066853
hgdprs2066853
ensemblrs2066853
gopubmedrs2066853
geneviewrs2066853
scholarrs2066853
googlers2066853
pharmgkbrs2066853
gwascentralrs2066853
openSNPrs2066853
23andMers2066853
23andMe allrs2066853
SNP Nexus

SNPshotrs2066853
SNPdbers2066853
MSV3drs2066853
GWAS Ctlgrs2066853
GMAF0.2741
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs2066853 has been associated with increased risk for colorectal polyps depending on the amount of meat eaten or overall exposure to heterocyclic amines. [PMID 18268115OA-icon.png]

[PMID 18818557] lung cancer in a Chinese population heterozygous rs2158041 OR=1.53 for GA vs compared with the (G;G) and rs7811989 OR=1.48 for (G;A) compared with the GG genotype)

  • rs2066853 (p.Arg554Lys) and cumulative cigarette smoking and the Lys/Lys genotype conferred an increased risk of lung cancer in the heavy smokers OR=3.36


[PMID 19415745] Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women




[PMID 17160896OA-icon.png] Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.


[PMID 18545700OA-icon.png] Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan.


[PMID 18632753OA-icon.png] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18990750OA-icon.png] Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.


[PMID 22211302] The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations.


GET Evidence
AHR-R554K
aa_change Arg554Lys
aa_change_short R554K
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.221695
summary



[PMID 23168330] Genetic susceptibility to dioxin-like chemicals' induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism


[PMID 23528250] Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women


[PMID 23703535] Polymorphisms in Aryl Hydrocarbon Receptor Gene Are Associated With Idiopathic Male Factor Infertility


[PMID 22539616] Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts.


[PMID 23492909] Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers.