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rs2069837

From SNPedia

Orientationplus
Stabilizedplus
Make rs2069837(A;A)
Make rs2069837(A;G)
Make rs2069837(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position22728408
GeneIL6, MIR632
is asnp
is mentioned by
dbSNPrs2069837
ebirs2069837
HLIrs2069837
Exacrs2069837
Varsomers2069837
Maprs2069837
PheGenIrs2069837
hapmaprs2069837
1000 genomesrs2069837
hgdprs2069837
ensemblrs2069837
gopubmedrs2069837
geneviewrs2069837
scholarrs2069837
googlers2069837
pharmgkbrs2069837
gwascentralrs2069837
openSNPrs2069837
23andMers2069837
23andMe allrs2069837
SNP Nexus

SNPshotrs2069837
SNPdbers2069837
MSV3drs2069837
GWAS Ctlgrs2069837
GMAF0.1065
Max Magnitude
? (A;A) (A;G) (G;G) 28
In a study of 1,757 cases of Alzheimer's disease and 6,295 controls, an interaction was replicated between IL6 genotype rs2069837(A;A) and IL10 genotype rs1800871(C;C). The synergy factor (SF) was 1.63 (CI: 1.10-2.41, p = 0.01), controlling for age, gender and ApoE4 genotype.[PMID 19698145OA-icon.png]


[PMID 22272811OA-icon.png] Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease


[PMID 17847004OA-icon.png] Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance.


[PMID 18216863OA-icon.png] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.


[PMID 18436879OA-icon.png] Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.


[PMID 18496509OA-icon.png] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.


[PMID 18500540OA-icon.png] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.


[PMID 19267250OA-icon.png] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.


[PMID 19387461OA-icon.png] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.


[PMID 19401628OA-icon.png] Host genetics, steatosis and insulin resistance among African Americans and Caucasian Americans with hepatitis C virus genotype-1 infection.


[PMID 19729864OA-icon.png] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.


[PMID 23088295] A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels


[PMID 23180271] Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women


[PMID 23415255] Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study


[PMID 24903966OA-icon.png] The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy


[PMID 25789467OA-icon.png] Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study


[PMID 27535759] Polymorphisms of the interleukin 6 gene and additional gene-gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women.