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rs2070045

From SNPedia

Orientationplus
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Make rs2070045(G;G)
Make rs2070045(G;T)
Make rs2070045(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position121577381
GeneSORL1
is asnp
is mentioned by
dbSNPrs2070045
ebirs2070045
HLIrs2070045
Exacrs2070045
Varsomers2070045
Maprs2070045
PheGenIrs2070045
hapmaprs2070045
1000 genomesrs2070045
hgdprs2070045
ensemblrs2070045
gopubmedrs2070045
geneviewrs2070045
scholarrs2070045
googlers2070045
pharmgkbrs2070045
gwascentralrs2070045
openSNPrs2070045
23andMers2070045
23andMe allrs2070045
SNP Nexus

SNPshotrs2070045
SNPdbers2070045
MSV3drs2070045
GWAS Ctlgrs2070045
GMAF0.3214
Max Magnitude
? (G;G) (G;T) (T;T) 28
SNP rs2070045, a variant of the SORL1 gene, has been reported to be associated with Alzheimer's disease. [PMID 17220890OA-icon.png]

However, a subsequent study of over 2,000 patients found a weak (at best) association. [PMID 17949987OA-icon.png]


[PMID 18562096OA-icon.png] No association of SORL1 SNPs with Alzheimer's disease.


[PMID 18713574OA-icon.png] The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.


[PMID 18938222OA-icon.png] Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.


[PMID 19064752OA-icon.png] Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.


[PMID 19362127OA-icon.png] Endophenotypes in normal brain morphology and Alzheimer's disease: a review.


[PMID 19368828] Association of SORL1 gene variants with Alzheimer's disease.


[PMID 19906263OA-icon.png] Use of genetic variation as biomarkers for Alzheimer's disease.


[PMID 20061642OA-icon.png] Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.


[PMID 20574532OA-icon.png] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.


[PMID 20625269] Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population.


[PMID 24083537] SORL1 genetic variants modulate risk of amnestic mild cognitive impairment in northern Han Chinese


[PMID 24309291] Association between the SORL1 rs2070045 polymorphism and Late-onset Alzheimer's disease: Interaction with the ApoE genotype in the Chinese Han population


[PMID 23318115OA-icon.png] Sortilin receptor 1 predicts longitudinal cognitive change.


[PMID 26268719OA-icon.png] Sex Moderates the Effects of the Sorl1 Gene rs2070045 Polymorphism on Cognitive Impairment and Disruption of the Cingulum Integrity in Healthy Elderly


[PMID 26611835] Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.