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rs2070106

From SNPedia

Orientationplus
Stabilizedplus
Make rs2070106(A;A)
Make rs2070106(A;G)
Make rs2070106(G;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position41973846
GeneCNP
is asnp
is mentioned by
dbSNPrs2070106
ebirs2070106
HLIrs2070106
Exacrs2070106
Varsomers2070106
Maprs2070106
PheGenIrs2070106
hapmaprs2070106
1000 genomesrs2070106
hgdprs2070106
ensemblrs2070106
gopubmedrs2070106
geneviewrs2070106
scholarrs2070106
googlers2070106
pharmgkbrs2070106
gwascentralrs2070106
openSNPrs2070106
23andMers2070106
23andMe allrs2070106
SNP Nexus

SNPshotrs2070106
SNPdbers2070106
MSV3drs2070106
GWAS Ctlgrs2070106
GMAF0.2626
Max Magnitude
? (A;A) (A;G) (G;G) 28

Based on a study of 790 individuals from 245 nuclear families (220 families were European Caucasian; 300 of the probands had a diagosis of schizophrenia), the rs2070106(G) allele was overtransmitted to affected offspring.[PMID 18496213]

This actually conflicts with a previous report [PMID 16389193] in which the rs2070106(A) allele was identified (also in Caucasians) in a combined gene association/expression study as associated with schizophrenia.

This is either a case of the "flip-flop" phenomenon [PMID 17273975OA-icon.png] in which multilocus effects and variation in interlocus correlations reverse a previously reported association, or perhaps more likely, a false positive.


[PMID 17306456] Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population.


[PMID 17964117OA-icon.png] Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.


[PMID 18289148] Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.


[PMID 19348671OA-icon.png] No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis.


[PMID 22473874OA-icon.png] A myelin gene causative of a catatonia-depression syndrome upon aging.


[PMID 23032943OA-icon.png] The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives