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rs2070874

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
Make rs2070874(C;T)
Make rs2070874(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position132674018
GeneIL4
is asnp
is mentioned by
dbSNPrs2070874
ebirs2070874
HLIrs2070874
Exacrs2070874
Varsomers2070874
Maprs2070874
PheGenIrs2070874
hapmaprs2070874
1000 genomesrs2070874
hgdprs2070874
ensemblrs2070874
gopubmedrs2070874
geneviewrs2070874
scholarrs2070874
googlers2070874
pharmgkbrs2070874
gwascentralrs2070874
openSNPrs2070874
23andMers2070874
23andMe allrs2070874
SNP Nexus

SNPshotrs2070874
SNPdbers2070874
MSV3drs2070874
GWAS Ctlgrs2070874
GMAF0.4279
Max Magnitude0
rs2070874 is a SNP in the promoter region of the interleukin 4 IL4 gene.

This SNP is one of five SNPs reported to be useful in a SNP set defining the risk of dying from prostate cancer among patients with the disease; see gs242 and gs243.

? (C;C) (C;T) (T;T) 28
[PMID 17713557OA-icon.png] Visceral leishmaniasis (VL) caused by Leishmania chagasi is endemic to northeast Brazil. A positive delayed-type hypersensitivity skin test response (DTH+) is a marker for acquired resistance to disease. the DTH- phenotype was associated with SNP rs2070874 at IL4 (OR 3.14; P=0.006; 95% CI=1.38-7.14), and SNP rs30740 between LECT2 and TGFBI (OR 3.00; P=0.042; 95% CI=1.04-8.65)
Neighborrs2243250
Distance556


[PMID 19254294] Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.


[PMID 19058298] Promoter polymorphisms of IL2, IL4, and risk of gastric cancer in a high-risk Chinese population


[PMID 20032229] Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms


[PMID 20332709] Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9 and IL-13 with Graves' disease

[PMID 20921925] Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity


[PMID 22053598] Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population


[PMID 22377791] Association of genetic polymorphisms of interleukins with new-onset diabetes after transplantation in renal transplantation


[PMID 15570643] Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis.


[PMID 15660293OA-icon.png] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.


[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.


[PMID 17303794OA-icon.png] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 18056382OA-icon.png] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.


[PMID 18454680OA-icon.png] Genetic basis for adverse events after smallpox vaccination.


[PMID 18538381] Clinical and genetic risk factors of self-reported penicillin allergy.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18781131OA-icon.png] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 19468064OA-icon.png] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.


[PMID 19840389OA-icon.png] Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.


[PMID 20015396OA-icon.png] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.


[PMID 20525402OA-icon.png] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 21320344OA-icon.png] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.


[PMID 21387019OA-icon.png] Differences in candidate gene association between European ancestry and African American asthmatic children.


[PMID 21501388] Association between interleukin-4 gene polymorphisms and intracerebral haemorrhage in Korean population.


[PMID 22528336] Association study of interleukin-4 polymorphisms with paranoid schizophrenia in the Polish population: a critical approach.


[PMID 23572437] Three common polymorphisms in the IL-4 gene and cancer risk: A meta-analysis involving 5,392 cases and 6,930 controls


[PMID 23651591] Association of polymorphisms in the interleukin-4 gene with response to hepatitis B vaccine and susceptibility to hepatitis B virus infection: a meta-analysis


[PMID 23654077] IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients


[PMID 23668806OA-icon.png] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns


[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma


[PMID 23964553] Relationship between polymorphisms in IL4 and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study


[PMID 24463336] Association of Interleukin-4 genetic polymorphisms with sporadic Alzheimer's disease in Chinese Han population


[PMID 22573572] Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).


[PMID 22824342] Association of polymorphisms of cytokine and TLR-2 genes with long-term immunity to hepatitis B in children vaccinated early in life.


[PMID 22884982] Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.


[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 23663310OA-icon.png] Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.


[PMID 25295591OA-icon.png] Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population


[PMID 25768087OA-icon.png] An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study


[PMID 25785117OA-icon.png] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis


[PMID 26681045] Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis.