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rs2090409

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) age at menarche ~2 months later on average
(G;T) age at menarche ~1 month later on average
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome9
Position106204807
is asnp
is mentioned by
dbSNPrs2090409
ebirs2090409
HLIrs2090409
Exacrs2090409
Varsomers2090409
Maprs2090409
PheGenIrs2090409
hapmaprs2090409
1000 genomesrs2090409
hgdprs2090409
ensemblrs2090409
gopubmedrs2090409
geneviewrs2090409
scholarrs2090409
googlers2090409
pharmgkbrs2090409
gwascentralrs2090409
openSNPrs2090409
23andMers2090409
23andMe allrs2090409
SNP Nexus

SNPshotrs2090409
SNPdbers2090409
MSV3drs2090409
GWAS Ctlgrs2090409
GMAF0.3669
Max Magnitude
? (G;G) (G;T) (T;T) 28
rs2090409 is a SNP from chromosomal region 9q31.2 showing the strongest association with age at menarche in a study of 17,500 Icelandic women.

Per copy carried of the rs2090409(A) allele, age at menarche is delayed about 1 month.

GWAS snp
PMID [PMID 19448620OA-icon.png]
Trait Menarche
Title Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
Risk Allele A
P-val 2E-9
Odds Ratio 0.10 [0.06-0.14] years younger
GWAS snp
PMID [PMID 21102462OA-icon.png]
Trait
Title Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Risk Allele A
P-val 2E-33
Odds Ratio 4.7000 [3.92-5.48] week decrease
OMIM612883
Desc
Variant
Relatedalso


GET Evidence
rs2090409
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.37069
summary



GWAS snp
PMID [PMID 23449627OA-icon.png]
Trait Pubertal anthropometrics
Title Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Risk Allele C
P-val 2E-6
Odds Ratio .11 [0.065-0.155] unit increase