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rs210138

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
(G;G) 2.7 Testicular Cancer
Make rs210138(A;G)
ReferenceGRCh38 38.1/141
Chromosome6
Position33574761
GeneBAK1
is asnp
is mentioned by
dbSNPrs210138
ebirs210138
HLIrs210138
Exacrs210138
Varsomers210138
Maprs210138
PheGenIrs210138
hapmaprs210138
1000 genomesrs210138
hgdprs210138
ensemblrs210138
gopubmedrs210138
geneviewrs210138
scholarrs210138
googlers210138
pharmgkbrs210138
gwascentralrs210138
openSNPrs210138
23andMers210138
23andMe allrs210138
SNP Nexus

SNPshotrs210138
SNPdbers210138
MSV3drs210138
GWAS Ctlgrs210138
GMAF0.241
Max Magnitude2.7
? (A;A) (A;G) (G;G) 28

23andMe blog each rs210138(G) was found to increase the odds of testicular cancer by 1.5x

GWAS snp
PMID [PMID 19483681OA-icon.png]
Trait Testicular germ cell tumor
Title A genome-wide association study of testicular germ cell tumor
Risk Allele G
P-val 1E-13
Odds Ratio 1.50 [1.28-1.75]
OMIM273300
Desc
Variant
Relatedalso
[PMID 21617256OA-icon.png] Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour


[PMID 22072546] Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.


GET Evidence
rs210138
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.210938
summary



GWAS snp
PMID [PMID 23666239OA-icon.png]
Trait Testicular germ cell tumor
Title Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Risk Allele G
P-val 3E-7
Odds Ratio 1.62 [1.35-1.95]
GWAS snp
PMID [PMID 23666240OA-icon.png]
Trait Testicular germ cell tumor
Title Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
Risk Allele G
P-val 2E-24
Odds Ratio 1.44 [1.30-1.61]