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rs2149954

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.2 slight association with longer life (longevity)
(A;G) 1.1 slight association with longer life (longevity)
(G;G) 0 common/normal
ReferenceGRCh38 38.1/142
Chromosome5
Position158393594
GeneLOC101927697
is asnp
is mentioned by
dbSNPrs2149954
ebirs2149954
HLIrs2149954
Exacrs2149954
Varsomers2149954
Maprs2149954
PheGenIrs2149954
hapmaprs2149954
1000 genomesrs2149954
hgdprs2149954
ensemblrs2149954
gopubmedrs2149954
geneviewrs2149954
scholarrs2149954
googlers2149954
pharmgkbrs2149954
gwascentralrs2149954
openSNPrs2149954
23andMers2149954
23andMe allrs2149954
SNP Nexus

SNPshotrs2149954
SNPdbers2149954
MSV3drs2149954
GWAS Ctlgrs2149954
Max Magnitude1.2

A genome-wide association meta-analysis of 7,729 long-lived individuals of European descent (≥ 85 years) and 16,121 younger controls (<65 years), followed by replication in an additional set of 13,060 long-lived individuals and 61,156 controls, found a (slight) association with longevity, as reflected by survival to ages beyond 90 years, for rs2149954, (OR 1.10, p = 1.74 × 10e-8). The less common rs2149954(A) allele (as represented in dbSNP orientation) is associated with low blood pressure in middle age and decreased cardiovascular mortality risk (independent of blood pressure).[PMID 24688116OA-icon.png]

? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 24688116OA-icon.png]
Trait Longevity (85 years and older)
Title Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
Risk Allele T
P-val 4E-6
Odds Ratio 1.07 [1.04-1.09]


[PMID 27707806] Replication of Genome-Wide Association Study Findings of Longevity in White, African American, and Hispanic Women: The Women's Health Initiative.