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rs2167270

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Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0.79x reduced risk for colon cancer
(A;G) 0 normal
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome7
Position128241296
GeneLEP
is asnp
is mentioned by
dbSNPrs2167270
ebirs2167270
HLIrs2167270
Exacrs2167270
Varsomers2167270
Maprs2167270
PheGenIrs2167270
hapmaprs2167270
1000 genomesrs2167270
hgdprs2167270
ensemblrs2167270
gopubmedrs2167270
geneviewrs2167270
scholarrs2167270
googlers2167270
pharmgkbrs2167270
gwascentralrs2167270
openSNPrs2167270
23andMers2167270
23andMe allrs2167270
SNP Nexus

SNPshotrs2167270
SNPdbers2167270
MSV3drs2167270
GWAS Ctlgrs2167270
GMAF0.3503
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs2167270 is a SNP in the leptin LEP gene.

In a study of ~1,500 colon cancer patients, the rs2167270(A;A) genotype was underrepresented, leading to an odds ratio of 0.79 (CI: 0.64-0.98).[PMID 18059035OA-icon.png]


[PMID 20140086OA-icon.png] Genetic Variation at Selected SNPs in the Leptin Gene and Association of Alleles with Markers of Kidney Disease in a Xhosa Population of South Africa


[PMID 21512510] The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents


[PMID 22666399OA-icon.png] Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study

[PMID 15197684OA-icon.png] Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.

[PMID 19035456OA-icon.png] Adipokine genes and prostate cancer risk.

[PMID 19204185OA-icon.png] Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.

[PMID 19593725OA-icon.png] Association of maternally inherited GNAS alleles with African-American male birth weight.

[PMID 21385539] Lack of association between LEP rs2167270 (19 G>A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis.


[PMID 23840460OA-icon.png] Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population


[PMID 22537818] Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women.


[PMID 22975643OA-icon.png] Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.


[PMID 24845032] Association of LEP A19G polymorphism with cancer risk: a systematic review and pooled analysis


[PMID 25810718OA-icon.png] Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer


[PMID 26167411] Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian population