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rs2171492(T;T)

From SNPedia

Higher prostate cancer risk
Is agenotype
ofrs2171492
GeneCPA4
Chromosome7
Position130,310,900
mentionedby
Magnitude2
ReputeBad
Geno Mag Summary
(T;T) 2 Higher prostate cancer risk

Results: The nonsynonymous coding SNP (rs2171492, Cys303Gly) in CPA4 was associated with an increased risk of aggressive prostate cancer among younger patients (<66 years).

Specifically, men carrying the TT genotype had an approximately two-fold increased risk for being diagnosed with intermediate-to-high risk disease (Odds Ratio=1.83, p=0.04). In the overall population (all ages) none of the CPA4 SNPs demonstrated a statistically significant association with prostate cancer.

[PMID 19245716OA-icon.png]