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rs2177369

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1.5 1.5x increased risk for Alzheimer's disease
(C;T) 0 normal
(T;T) 0 normal
ReferenceGRCh38 38.1/142
Chromosome10
Position49635683
GeneCHAT
is asnp
is mentioned by
dbSNPrs2177369
ebirs2177369
HLIrs2177369
Exacrs2177369
Varsomers2177369
Maprs2177369
PheGenIrs2177369
hapmaprs2177369
1000 genomesrs2177369
hgdprs2177369
ensemblrs2177369
gopubmedrs2177369
geneviewrs2177369
scholarrs2177369
googlers2177369
pharmgkbrs2177369
gwascentralrs2177369
openSNPrs2177369
23andMers2177369
23andMe allrs2177369
SNP Nexus

SNPshotrs2177369
SNPdbers2177369
MSV3drs2177369
GWAS Ctlgrs2177369
GMAF0.2787
Max Magnitude1.5
A case-control study of 471 Italian late-onset Alzheimer's disease patients aged 60 years or older, and 254 subjects with no neurodegenerative disorders serving as the control group, found that the rs2177369(G;G) genotype (in dbSNP orientation) a risk factor with an odds ratio of 1.56 (CI: 1.10-2.22, p = 0.01). Refreshingly, the authors call their results "far from definitive".[PMID 18780301]


[PMID 27272392] A meta-analysis of 16,000 Alzheimer's cases finds that rs2177369 is associated (albeit not with a high odds ratio) with the disease in Caucasians.


[PMID 16223550OA-icon.png] Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease.