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rs2209972

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) higher risk for PCOS?
(C;T) higher risk for PCOS?
(T;T) normal risk
ReferenceGRCh38 38.1/142
Chromosome10
Position92419271
GeneMARK2P9
is asnp
is mentioned by
dbSNPrs2209972
ebirs2209972
HLIrs2209972
Exacrs2209972
Varsomers2209972
Maprs2209972
PheGenIrs2209972
hapmaprs2209972
1000 genomesrs2209972
hgdprs2209972
ensemblrs2209972
gopubmedrs2209972
geneviewrs2209972
scholarrs2209972
googlers2209972
pharmgkbrs2209972
gwascentralrs2209972
openSNPrs2209972
23andMers2209972
23andMe allrs2209972
SNP Nexus

SNPshotrs2209972
SNPdbers2209972
MSV3drs2209972
GWAS Ctlgrs2209972
GMAF0.4233
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs2209972, a SNP associated with the insulin-degrading enzyme gene IDE, has been identified as occuring at higher frequency in Chinese female patients with polycystic ovary syndrome (PCOS). The IDE gene has been linked to type-2 diabetes, and many patients with PCOS have endocrine abnormalities that suggest a shared etiology with type-2 diabetes.

The risk allele for this SNP is rs2209972(C), and in this study comparing ~300 patients to an equal number of controls the rs2209972(C;C) and rs2209972(C;T) genotypes were associated with higher fasting insulin levels, a higher body mass index (BMI), and (theoretically) insulin resistance (HOMA-IR) than rs2209972(T;T) carriers. [PMID 17953957]


[PMID 24355596] C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study