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rs2227956

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(T;T) 0
Make rs2227956(C;C)
Make rs2227956(C;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position31810495
GeneHSPA1L
is asnp
is mentioned by
dbSNPrs2227956
ebirs2227956
HLIrs2227956
Exacrs2227956
Varsomers2227956
Maprs2227956
PheGenIrs2227956
hapmaprs2227956
1000 genomesrs2227956
hgdprs2227956
ensemblrs2227956
gopubmedrs2227956
geneviewrs2227956
scholarrs2227956
googlers2227956
pharmgkbrs2227956
gwascentralrs2227956
openSNPrs2227956
23andMers2227956
23andMe allrs2227956
SNP Nexus

SNPshotrs2227956
SNPdbers2227956
MSV3drs2227956
GWAS Ctlgrs2227956
GMAF0.1221
Max Magnitude0
? (C;C) (C;T) (T;T) 28
[PMID 18813331OA-icon.png] rs2227956 in HSP70-hom, resulted in a significant association with noise-induced hearing loss


[PMID 19351530] Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4,000 meters.


OMIM613035
Desc
Variant
Relatedalso
[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 17009593OA-icon.png] Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes.


[PMID 17009596OA-icon.png] Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.


[PMID 18194558OA-icon.png] A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.


[PMID 18299791] Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia.


[PMID 18551993] SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.


[PMID 19143815OA-icon.png] MHC fine mapping of human type 1 diabetes using the T1DGC data.


[PMID 19439993] The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients.


[PMID 19582769] Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.


[PMID 20012387OA-icon.png] HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility.


GET Evidence
HSPA1L-T493M
aa_change Thr493Met
aa_change_short T493M
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.87256
summary Protection from hypersensitivity to carbamazepine.



[PMID 24872649OA-icon.png] Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis


[PMID 25789467OA-icon.png] Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study


[PMID 26670457] Heat shock protein 70 gene polymorphisms' influence on the electrophysiology of long QT syndrome.


[PMID 27609295] Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.