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rs2228044

From SNPedia

Orientationminus
Stabilizedminus
Make rs2228044(C;C)
Make rs2228044(C;G)
Make rs2228044(G;G)
ReferenceGRCh38 38.1/141
Chromosome5
Position55968325
GeneIL6ST
is asnp
is mentioned by
dbSNPrs2228044
ebirs2228044
HLIrs2228044
Exacrs2228044
Varsomers2228044
Maprs2228044
PheGenIrs2228044
hapmaprs2228044
1000 genomesrs2228044
hgdprs2228044
ensemblrs2228044
gopubmedrs2228044
geneviewrs2228044
scholarrs2228044
googlers2228044
pharmgkbrs2228044
gwascentralrs2228044
openSNPrs2228044
23andMers2228044
23andMe allrs2228044
SNP Nexus

SNPshotrs2228044
SNPdbers2228044
MSV3drs2228044
GWAS Ctlgrs2228044
Merged fromRs3729960
GMAF0.1873
Max Magnitude

[PMID 17664290OA-icon.png] Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man.


[PMID 18223637] A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 19401444OA-icon.png] Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism.


[PMID 21981268] Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis.

GET Evidence
IL6ST-G148R
aa_change Gly148Arg
aa_change_short G148R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.223875
summary



[PMID 22742541] No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis