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rs2229094

From SNPedia

Orientationplus
Stabilizedplus
Make rs2229094(C;C)
Make rs2229094(C;T)
Make rs2229094(T;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position31572779
GeneHLA-DQA1, LTA
is asnp
is mentioned by
dbSNPrs2229094
ebirs2229094
HLIrs2229094
Exacrs2229094
Varsomers2229094
Maprs2229094
PheGenIrs2229094
hapmaprs2229094
1000 genomesrs2229094
hgdprs2229094
ensemblrs2229094
gopubmedrs2229094
geneviewrs2229094
scholarrs2229094
googlers2229094
pharmgkbrs2229094
gwascentralrs2229094
openSNPrs2229094
23andMers2229094
23andMe allrs2229094
SNP Nexus

SNPshotrs2229094
SNPdbers2229094
MSV3drs2229094
GWAS Ctlgrs2229094
GMAF0.2677
Max Magnitude
? (C;C) (C;T) (T;T) 28
Associated with at least one "mortality outcome" in a study of ~10,000 individuals.[PMID 18263601]

[PMID 18700950OA-icon.png] 827 males and 709 females, 606 subjects without cancer and 930 subjects with various cancers

  • rs2229094(A;A) (T495C, C13R) associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 - 2.65)

in males but not in females

Neighborrs1041981
Distance228


[PMID 20177654] Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians


[PMID 20663564] A Strong Genetic Association between the Tumor Necrosis Factor Locus and Proliferative Vitreoretinopathy: The Retina 4 Project


[PMID 21628868] Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in han chinese


[PMID 16839190OA-icon.png] Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.


[PMID 16846490OA-icon.png] Lemierre's syndrome and genetic polymorphisms: a case report.


[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.


[PMID 18398712] No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes.


[PMID 18598365OA-icon.png] Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia.


[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.


[PMID 18704761OA-icon.png] Molecular genetics of myocardial infarction.


[PMID 18715339OA-icon.png] Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 19098314] Development of predictive models of proliferative vitreoretinopathy based on genetic variables: the Retina 4 project.


[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


GET Evidence
LTA-C13R
aa_change Cys13Arg
aa_change_short C13R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.273477
summary



[PMID 23051989] Investigation of lymphotoxin alpha genetic variants in migraine.