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rs2229765(A;A)

From SNPedia

Lower IGF-1 levels; some reported associations with longevity as well as certain cancers
Is agenotype
ofrs2229765
GeneIGF1R
Chromosome15
Position98,934,996
mentionedby
Magnitude2.1
Geno Mag Summary
(A;A) 2.1 Lower IGF-1 levels; some reported associations with longevity as well as certain cancers
(G;G) 1.1 Normal IGF-1 level

[PMID 18477064] rs2229765(A;A) associated with ischemic stroke (OR = 1.641, P = 0.022) in a Chinese population

After adjustment for smoking, alcohol drinking, history of hypertension, and body mass index, IGF-1R AA genotype was still significantly associated with an increased risk of IS (OR = 1.787, P = 0.029), compared with IGF-1R GG.


[PMID 25189651] Association of insulin-like growth factor-I receptor polymorphism with colorectal cancer development

The frequency of A-allele in advanced CRC was significantly higher then early CRC (52 vs. 37.7, OR = 1.78). According to genotype serum IGF-1 levels was significantly decreased in patients with GG genotype then patients with dominant genotypes. Our results showed a relationship between the +3179G>A polymorphism of the IGF-1R and serum IGF-1 with the progression of colorectal carcinoma.