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rs2229774

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common/normal
(C;T) 3 higher risk for anthracycline side-effects for childhood cancer patients
Make rs2229774(T;T)
ReferenceGRCh38.p2 38.2/144
Chromosome12
Position53211761
GeneRARG
is asnp
is mentioned by
dbSNPrs2229774
ebirs2229774
HLIrs2229774
Exacrs2229774
Varsomers2229774
Maprs2229774
PheGenIrs2229774
hapmaprs2229774
1000 genomesrs2229774
hgdprs2229774
ensemblrs2229774
gopubmedrs2229774
geneviewrs2229774
scholarrs2229774
googlers2229774
pharmgkbrs2229774
gwascentralrs2229774
openSNPrs2229774
23andMers2229774
23andMe allrs2229774
SNP Nexus

SNPshotrs2229774
SNPdbers2229774
MSV3drs2229774
GWAS Ctlgrs2229774
Max Magnitude3
? (C;C) (C;T) (T;T) 28

Genome Web news

rs2229774, also known as p.Ser427Leu, in the RARG gene ups cardiotoxicity risk by roughly five times in children treated with the cancer drug anthracycline, based on a GWAS of a small number of anthracycline-treated childhood cancer patients (32 cases in the original discovery cohort and 22 in the replication population). The risk allele is the rare rs2229774(T) allele, in dbSNP orientation.10.1038/ng.3374