Possible increased risk of birth defects |
Geno
|
Mag
|
Summary
|
(C;C)
|
0
|
common/normal
|
(C;T)
|
1.25
|
Possible increased risk of birth defects
|
(T;T)
|
1.5
|
Slightly (~1.5x) higher risk for Caucasian mothers to give birth to NTD children
|
Some studies, predominanty amongst Caucasians, have shown that presence of this mutation is associated with a slightly higher risk to give birth to children with neural tube defects; other studies have demonstrated association with heart defects in homozygous offspring - See discussion at rs2236225.