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rs2237892

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common in complete genomics
Make rs2237892(C;T)
Make rs2237892(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position2818521
GeneKCNQ1
is asnp
is mentioned by
dbSNPrs2237892
ebirs2237892
HLIrs2237892
Exacrs2237892
Varsomers2237892
Maprs2237892
PheGenIrs2237892
hapmaprs2237892
1000 genomesrs2237892
hgdprs2237892
ensemblrs2237892
gopubmedrs2237892
geneviewrs2237892
scholarrs2237892
googlers2237892
pharmgkbrs2237892
gwascentralrs2237892
openSNPrs2237892
23andMers2237892
23andMe allrs2237892
SNP Nexus

SNPshotrs2237892
SNPdbers2237892
MSV3drs2237892
GWAS Ctlgrs2237892
GMAF0.1699
Max Magnitude0
? (C;C) (C;T) (T;T) 28

23andMe blog rs2237892(C) is associated with an increased risk for developing type-2 diabetes.

each C at rs2237892 increased the odds of type 2 diabetes by 1.4 times, compared to the TT genotype. It’s important to note, however, that the C version is actually pretty common.

In Asian populations, the C version of rs2237892 increased a person’s odds of type 2 diabetes by 1.42 times compared to people with TT. But because about 50% of the Asian population is actually CT at this SNP, it could be viewed that CC has 1.3 times the odds compared to typical, while TT has 0.61 times the typical odds.

In European populations, about 85% of people are CC. This means that the results of Yasuda et al really show that compared to most Europeans, people with CT at rs2237892 have 0.78 times the typical odds of developing type 2 diabetes, and the odds for people with TT are 0.52 times typical.


[PMID 19366866OA-icon.png] Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion

GWAS snp
PMID [PMID 18711367]
Trait Type 2 diabetes
Title Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Risk Allele C
P-val 2E-42
Odds Ratio 1.40 [1.34-1.47]
GWAS snp
PMID [PMID 19401414OA-icon.png]
Trait Type 2 diabetes
Title Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
Risk Allele C
P-val 1E-26
Odds Ratio 1.33 [1.27-1.41]

[PMID 19448982OA-icon.png] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China

[PMID 19516902OA-icon.png] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load


[PMID 19575309] Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population

OMIM125853
DescDIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
Variant
Relatedalso

[PMID 19308350] Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population

[PMID 19850681] Association of KCNQ1 Polymorphisms with the Gestational Diabetes Mellitus in Korean Women



[PMID 20512086] Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: A case-control study and meta-analysis

GWAS snp
PMID [PMID 21573907OA-icon.png]
Trait
Title Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
Risk Allele C
P-val 0.000004
Odds Ratio 1.2000 [1.11-1.29]


[PMID 22403629OA-icon.png] Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp


[PMID 22479571OA-icon.png] Several Polymorphisms of KCNQ1 Gene Are Associated with Plasma Lipid Levels in General Chinese Populations


[PMID 22206064] KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects


[PMID 22693455OA-icon.png] Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

[PMID 18991055] Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.

[PMID 19033397OA-icon.png] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

[PMID 19252135OA-icon.png] Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.

[PMID 19323962OA-icon.png] Genome-wide association studies in type 2 diabetes.

[PMID 19460916OA-icon.png] Genetic architecture of type 2 diabetes: recent progress and clinical implications.

[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19556355] Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

[PMID 19750184OA-icon.png] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19862325OA-icon.png] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

[PMID 20509872OA-icon.png] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

[PMID 20606385] Polymorphisms in KCNQ1 are associated with gestational diabetes in a Korean population.

[PMID 20701788OA-icon.png] KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.

[PMID 21261977OA-icon.png] Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.

[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 21289621] Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.

[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

[PMID 22377714] Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.

[PMID 22414228] KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients.

[PMID 22461567OA-icon.png] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.


GET Evidence
rs2237892
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.0793651
summary



[PMID 23133642OA-icon.png] The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis


[PMID 23271129] Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes


[PMID 23029294OA-icon.png] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus

GWAS snp
PMID [PMID 22961080OA-icon.png]
Trait Type 2 diabetes
Title A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Risk Allele C
P-val 1E-7
Odds Ratio 1.32 [1.19-1.46]


[PMID 23786590] Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis


[PMID 22790062] Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes.


[PMID 22923468OA-icon.png] Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.


[PMID 23107108] Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs.


[PMID 23630301OA-icon.png] Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.


[PMID 23692438] Association between KCNQ1 genetic variants and QT interval in a Chinese population.

GWAS snp
PMID [PMID 23945395]
Trait Type 2 diabetes
Title Genome-wide association study identifies three novel loci for type 2 diabetes.
Risk Allele C
P-val 4E-29
Odds Ratio 1.30 [1.24-1.36]
GWAS snp
PMID [PMID 24861553OA-icon.png]
Trait Body mass index
Title Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Risk Allele T
P-val 9E-13
Odds Ratio .03 [0.022-0.038] unit increase


[PMID 26678516] Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population.