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rs2237895

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Orientationplus
Stabilizedplus
Make rs2237895(A;A)
Make rs2237895(A;C)
Make rs2237895(C;C)
ReferenceGRCh38 38.1/141
Chromosome11
Position2835964
GeneKCNQ1
is asnp
is mentioned by
dbSNPrs2237895
ebirs2237895
HLIrs2237895
Exacrs2237895
Varsomers2237895
Maprs2237895
PheGenIrs2237895
hapmaprs2237895
1000 genomesrs2237895
hgdprs2237895
ensemblrs2237895
gopubmedrs2237895
geneviewrs2237895
scholarrs2237895
googlers2237895
pharmgkbrs2237895
gwascentralrs2237895
openSNPrs2237895
23andMers2237895
23andMe allrs2237895
SNP Nexus

SNPshotrs2237895
SNPdbers2237895
MSV3drs2237895
GWAS Ctlgrs2237895
GMAF0.3476
Max Magnitude
nature type-2 diabetes
  • rs2237895, P = 7.3 times 10-9; OR = 1.32, 95% CI = 1.20–1.45

[PMID 19366866OA-icon.png] Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion

[PMID 19448982OA-icon.png] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China

[PMID 19516902OA-icon.png] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load


[PMID 19575309] Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population

[PMID 19584308OA-icon.png] A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

[PMID 19308350] Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population

[PMID 19850681] Association of KCNQ1 Polymorphisms with the Gestational Diabetes Mellitus in Korean Women

GWAS snp
PMID [PMID 20174558OA-icon.png]
Trait Type 2 diabetes
Title A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese
Risk Allele C
P-val 1E-9
Odds Ratio 1.29 [1.19-1.40]


[PMID 22479571OA-icon.png] Several Polymorphisms of KCNQ1 Gene Are Associated with Plasma Lipid Levels in General Chinese Populations


[PMID 22206064] KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects

[PMID 18711366] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.

[PMID 19207020OA-icon.png] Meta-analysis in genome-wide association studies.

[PMID 19252135OA-icon.png] Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.

[PMID 19556355] Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

[PMID 20606385] Polymorphisms in KCNQ1 are associated with gestational diabetes in a Korean population.

[PMID 20701788OA-icon.png] KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.

[PMID 21261977OA-icon.png] Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.

[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 21289621] Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.

[PMID 21291537OA-icon.png] Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes.

[PMID 21355884] KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients.

[PMID 22414228] KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients.

[PMID 22461567OA-icon.png] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.


[PMID 23133642OA-icon.png] The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis


[PMID 23139357OA-icon.png] Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets


[PMID 23271129] Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes


[PMID 23029294OA-icon.png] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus


[PMID 23786590] Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis


[PMID 22696034] KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes.


[PMID 22790062] Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes.


[PMID 23107108] Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs.


[PMID 23334806OA-icon.png] Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.


[PMID 23630301OA-icon.png] Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.


[PMID 23692438] Association between KCNQ1 genetic variants and QT interval in a Chinese population.


[PMID 26109524] Role of high-risk variants in the development of impaired glucose metabolism was modified by birth weight in Han Chinese


[PMID 27155871] Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.