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rs2239704

From SNPedia

Orientationminus
Stabilizedminus
Make rs2239704(G;G)
Make rs2239704(G;T)
Make rs2239704(T;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position31572364
GeneHLA-DQA1, LTA
is asnp
is mentioned by
dbSNPrs2239704
ebirs2239704
HLIrs2239704
Exacrs2239704
Varsomers2239704
Maprs2239704
PheGenIrs2239704
hapmaprs2239704
1000 genomesrs2239704
hgdprs2239704
ensemblrs2239704
gopubmedrs2239704
geneviewrs2239704
scholarrs2239704
googlers2239704
pharmgkbrs2239704
gwascentralrs2239704
openSNPrs2239704
23andMers2239704
23andMe allrs2239704
SNP Nexus

SNPshotrs2239704
SNPdbers2239704
MSV3drs2239704
GWAS Ctlgrs2239704
GMAF0.3476
Max Magnitude
? (G;G) (G;T) (T;T) 28
OMIM153440
DescLYMPHOTOXIN-ALPHA; LTA
Variant
Relatedalso

A US study [PMID 17018637] of 1,172 lymphoma patients and 982 controls looked at 57 SNPs in 36 immune function genes. Five SNPs in two cytokine genes, TNF and LTA, were associated with a 1.31x increase in Non-Hodgkin Lymphoma (OR, 1.31; 95% CI, 1.06-1.63; P = 0.01) and with a 1.64x increase in the subtype known as diffuse large B cell lymphoma (OR, 1.64; 95% CI, 1.23-2.19; P = 0.0007). The other four SNPS are listed below. The cytokine genes affect inflammatory and innate immune responses.

OMIM153440
Desc
Variant0003
Relatedalso


[PMID 21628868] Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in han chinese


[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 17450233OA-icon.png] Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.


[PMID 18715339OA-icon.png] Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18990758OA-icon.png] Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19281305OA-icon.png] Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.


[PMID 20617178OA-icon.png] Leprosy and the adaptation of human toll-like receptor 1.


[PMID 23824834OA-icon.png] Genetic variation in the TLR and NF-κB genetic pathways and cervical and vulvar cancer risk: A population-based case-control study


[PMID 23071570OA-icon.png] Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.


[PMID 23647060] Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.