Have questions? Visit https://www.reddit.com/r/SNPedia

rs2241524

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) normal
(T;T) ~2x increased risk for lupus and MPA
ReferenceGRCh37 37.1/131
Chromosome19
Position55098667
GeneLILRA2
is asnp
is mentioned by
dbSNPrs2241524
ebirs2241524
HLIrs2241524
Exacrs2241524
Varsomers2241524
Maprs2241524
PheGenIrs2241524
hapmaprs2241524
1000 genomesrs2241524
hgdprs2241524
ensemblrs2241524
gopubmedrs2241524
geneviewrs2241524
scholarrs2241524
googlers2241524
pharmgkbrs2241524
gwascentralrs2241524
openSNPrs2241524
23andMers2241524
23andMe allrs2241524
SNP Nexus

SNPshotrs2241524
SNPdbers2241524
MSV3drs2241524
GWAS Ctlgrs2241524
GMAF0.1015
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs2241524 is a SNP in the LILRA2 gene that disrupts the splice acceptor site of intron 6.

Case-control association studies on 273 Japanese patients with systemic lupus erythematosus (SLE) and 50 patients with microscopic polyangiitis (MPA) showed an association between the homozygous rs2241524(T;T) genotype (as oriented in dbSNP). For the association with SLE, the odds ratio was 1.82 (CI: 1.02-3.24, p=0.041) and for MPA, the odds ratio was 2.52 (CI: 1.07-5.96, p=0.049).[PMID 18273033] [PMID 17903297OA-icon.png] Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.


[PMID 20236493OA-icon.png] The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.