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rs2243250

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 2 0.6x decreased risk for myocardial infarction if younger than 50
(T;T) 2 0.33x decreased risk for myocardial infarction if younger than 50
ReferenceGRCh38 38.1/141
Chromosome5
Position132673462
GeneIL4
is asnp
is mentioned by
dbSNPrs2243250
ebirs2243250
HLIrs2243250
Exacrs2243250
Varsomers2243250
Maprs2243250
PheGenIrs2243250
hapmaprs2243250
1000 genomesrs2243250
hgdprs2243250
ensemblrs2243250
gopubmedrs2243250
geneviewrs2243250
scholarrs2243250
googlers2243250
pharmgkbrs2243250
gwascentralrs2243250
openSNPrs2243250
23andMers2243250
23andMe allrs2243250
SNP Nexus

SNPshotrs2243250
SNPdbers2243250
MSV3drs2243250
GWAS Ctlgrs2243250
GMAF0.4844
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs2243250 is a SNP in the IL4 gene that is also known as the -589C>T SNP.

In 300 patients younger than 50 years the rs2243250(T) allele was associated with a reduced risk of myocardial infarction (odds ratio 0.57, CI: 0.34-0.95). This result was replicated in another study, where carriers of one or two -589T alleles also had a reduced risk (odds ratio 0.67, CI: 0.47-0.95), with a strong protective effect of the -598T allele in homozygous -589T (odds ratio 0.33, CI: 0.10-1.05).[PMID 18662263]

Neighborrs2070874
Distance556


[PMID 19351467] [Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like der-matitis induced by trichloroethylene.]


[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial


[PMID 20403914] Comprehensive analysis of the cytokine rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk

[PMID 20921925] Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity

[PMID 21195738] Association of an IL4 gene haplotype with Graves disease in children: Experimental study and meta-analysis


[PMID 22512783] Interleukin-4 Genetic Variants Correlate With Its Transcript And Protein Levels In Vitiligo Patients


[PMID 22377791] Association of genetic polymorphisms of interleukins with new-onset diabetes after transplantation in renal transplantation


[PMID 15660293OA-icon.png] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 16380915OA-icon.png] Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.


[PMID 16449530OA-icon.png] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.


[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).


[PMID 17303794OA-icon.png] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 17855802] Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels.


[PMID 18056382OA-icon.png] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.


[PMID 18064451] IL4 in the 5q31 context: association studies of type 1 diabetes and rheumatoid arthritis in the Spanish population.


[PMID 18466472OA-icon.png] Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.


[PMID 18466513OA-icon.png] Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.


[PMID 18466554OA-icon.png] Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests.


[PMID 18625055OA-icon.png] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.


[PMID 18687755OA-icon.png] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18847302OA-icon.png] Personalized vaccines: the emerging field of vaccinomics.


[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19126646OA-icon.png] Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19347053OA-icon.png] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.


[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19759553OA-icon.png] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 19956102OA-icon.png] Evidence for association of the TCF7 locus with type I diabetes.


[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.


[PMID 20015396OA-icon.png] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.


[PMID 20041166OA-icon.png] Common genetic variation and the control of HIV-1 in humans.


[PMID 20219689] Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis.


[PMID 20416077OA-icon.png] Identification of type 2 diabetes-associated combination of SNPs using support vector machine.


[PMID 20444268OA-icon.png] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.


[PMID 20459687OA-icon.png] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.


[PMID 20525402OA-icon.png] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.


[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.


[PMID 21385363OA-icon.png] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.


[PMID 21387019OA-icon.png] Differences in candidate gene association between European ancestry and African American asthmatic children.


[PMID 21501388] Association between interleukin-4 gene polymorphisms and intracerebral haemorrhage in Korean population.


[PMID 21562768] A study of the impact of cytokine gene polymorphism in acute rejection of renal transplant recipients.


[PMID 21819409OA-icon.png] Gene-vitamin D interactions on food sensitization: a prospective birth cohort study.


[PMID 22045834] Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.


[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.


[PMID 22528336] Association study of interleukin-4 polymorphisms with paranoid schizophrenia in the Polish population: a critical approach.


[PMID 22686937] Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency.


[PMID 23245479] The association between the IL-4, ADRβ2 and ADAM 33 gene polymorphisms and asthma in the Taiwanese population


[PMID 23572437] Three common polymorphisms in the IL-4 gene and cancer risk: A meta-analysis involving 5,392 cases and 6,930 controls


[PMID 23651591] Association of polymorphisms in the interleukin-4 gene with response to hepatitis B vaccine and susceptibility to hepatitis B virus infection: a meta-analysis


[PMID 23654077] IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients


[PMID 23668806OA-icon.png] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns


[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma


[PMID 23964553] Relationship between polymorphisms in IL4 and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study


[PMID 24463336] Association of Interleukin-4 genetic polymorphisms with sporadic Alzheimer's disease in Chinese Han population


[PMID 22484276] Effects of cytokine and cytokine receptor gene variation on high anti-HB titers: following up on Taiwan's neonatal hepatitis B immunization program.


[PMID 22652416] Interleukin-4 rs2243250 polymorphism is associated with asthma among Caucasians and related to atopic asthma.


[PMID 22824342] Association of polymorphisms of cytokine and TLR-2 genes with long-term immunity to hepatitis B in children vaccinated early in life.


[PMID 22884982] Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.


[PMID 23029430OA-icon.png] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.


[PMID 23376457] Cytokine gene polymorphisms in Tunisian endemic pemphigus foliaceus: a possible role of il-4 variants.


[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 23768103] IL-4 -590C/T polymorphism and susceptibility to liver disease: a meta-analysis and meta-regression.


[PMID 23797532OA-icon.png] Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization.


[PMID 25239315] An interleukin-4 polymorphism is associated with susceptibility to Clostridium difficile infection in patients with inflammatory bowel disease: Results of a retrospective cohort study


[PMID 25295591OA-icon.png] Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population


[PMID 25768087OA-icon.png] An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study


[PMID 25785117OA-icon.png] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis


[PMID 26426602] Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study


[PMID 26448013OA-icon.png] High Incidence of Malaria Along the Sino-Burmese Border Is Associated With Polymorphisms of CR1, IL-1A, IL-4R, IL-4, NOS, and TNF, But Not With G6PD Deficiency


[PMID 27472286] CCL2, CCL5, IL4 and IL15 Gene Polymorphisms in Women with Gestational Diabetes Mellitus.