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rs2257212(A;A)

From SNPedia

The A allele ( assumed to be T) responds better to sorafenib in HCC
Is agenotype
ofrs2257212
GeneSLC15A2
Chromosome3
Position121,924,957
mentionedby
Magnitude2.0
ReputeGood
Geno Mag Summary
(A;A) 2 The A allele ( assumed to be T) responds better to sorafenib in HCC
(A;G) 2 AG as AA responds better to sorafenib during HCC treatment
(G;G) 0 GG genotype responds less well to sorafenib during HCC treatment

Study has found that the AA genotype (TT?) genotype responds better to sorafenib than does the GG (CC?) genotype. As can be seen in Figure 2 from the article previously noted the Kaplan-Meier survival curves for the CC versus CT/TT genotypes diverged quite strongly. Approximately 5% of CT/TT genotypes survived beyond 2 years while none with CC survived beyond a year.,