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rs2267735

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 Associated with PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not males
(C;G) 1 One copy of risk allele = associated with mildly increased chance of PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not males
(G;G) 0 Normal variant of snp associated with PTSD, hyperarousal in females.
ReferenceGRCh38 38.1/141
Chromosome7
Position31095890
GeneADCYAP1R1
is asnp
is mentioned by
dbSNPrs2267735
ebirs2267735
HLIrs2267735
Exacrs2267735
Varsomers2267735
Maprs2267735
PheGenIrs2267735
hapmaprs2267735
1000 genomesrs2267735
hgdprs2267735
ensemblrs2267735
gopubmedrs2267735
geneviewrs2267735
scholarrs2267735
googlers2267735
pharmgkbrs2267735
gwascentralrs2267735
openSNPrs2267735
23andMers2267735
23andMe allrs2267735
SNP Nexus

SNPshotrs2267735
SNPdbers2267735
MSV3drs2267735
GWAS Ctlgrs2267735
GMAF0.4651
Max Magnitude2
? (C;C) (C;G) (G;G) 28

An SNP in a putative estrogen response element within the ADCYAP1R1 gene. C is the risk allele - associated with PTSD, hyperarousal in females.

[PMID 21350482OA-icon.png] Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). Predicts Post-traumatic stress disorder diagnoses and symptoms in females only. This may occur due to oestrogen regulation of ADCYAP1R1. Total PTSD symptoms are differentially associated with rs2267735 genotype (CC is high-risk variant) in females (p ≤ 0.001). Hyperarousal is the most robustly associated symptom with rs2267735 genotype (p = 0.0009). In a dominant/recessive model, even after controlling for childhood trauma, adult trauma, and age, genotype predicts total PTSD symptoms (p ≤ 0.001) and hyperarousal symptoms (p ≤ 0.0001). Fear discrimination (CS+ Startle minus CS− Startle) is impaired in females with rs2267735 ‘CC’ genotype. Dark enhanced startle (StartleDark – StartleLight) is significantly increased in females with rs2267735 ‘CC’ genotype.


[PMID 23280952OA-icon.png] ADCYAP1R1 GENOTYPE, POSTTRAUMATIC STRESS DISORDER, AND DEPRESSION AMONG WOMEN EXPOSED TO CHILDHOOD MALTREATMENT


[PMID 23394710] PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors


[PMID 23328528OA-icon.png] ADCYAP1R1 and asthma in Puerto Rican children.


[PMID 23505260OA-icon.png] ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females.


[PMID 25680674] Neural Mechanism of a Sex-Specific Risk Variant for Posttraumatic Stress Disorder in the Type I Receptor of the Pituitary Adenylate Cyclase Activating Polypeptide