Rs2268578

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is asnp
is mentioned by
dbSNPrs2268578
hapmaprs2268578
hgdprs2268578
ensemblrs2268578
gopubmedrs2268578
scholarrs2268578
googlers2268578
pharmgkbrs2268578
hgvbaseg2prs2268578
medrefsnprs2268578
23andMers2268578
SNP Nexus

GeneLUM
Chromosome12
Orientationminus
Position90025328
GenotypeEffect
rs2268578(C;C)normal
rs2268578(C;T)1.1x increased breast cancer risk
rs2268578(T;T)1.9x increased breast cancer risk


Genotypes Magnitude Summary
Rs2268578(C;C) 00 normal
Rs2268578(C;T) 1.1x increased breast cancer risk
Rs2268578(T;T) 1.9x increased breast cancer risk

rs2268578 is a SNP in the lumican LUM gene.

Two populations of patients with breast cancer, comprising ~800 cases from the Mayo Clinic and ~4,500 cases from East Anglia, England, were analyzed for SNP associations in the decorin and lumican genes. rs2268578 was associated with breast cancer in both populations; in combined analyses, the odds ratio for rs2268578(C;T) was 1.1 (CI: 0.9-1.2) and 1.9 (CI: 1.3-2.8, p 2 df = 0.001) for homozygotes. [PMID 19036156]

? (C;C) (C;T) (T;T)


[PMID 19843670] Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer