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rs2268578

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.1x increased breast cancer risk
(T;T) 1.9x increased breast cancer risk
ReferenceGRCh38 38.1/141
Chromosome12
Position91107421
GeneLUM
is asnp
is mentioned by
dbSNPrs2268578
ebirs2268578
HLIrs2268578
Exacrs2268578
Varsomers2268578
Maprs2268578
PheGenIrs2268578
hapmaprs2268578
1000 genomesrs2268578
hgdprs2268578
ensemblrs2268578
gopubmedrs2268578
geneviewrs2268578
scholarrs2268578
googlers2268578
pharmgkbrs2268578
gwascentralrs2268578
openSNPrs2268578
23andMers2268578
23andMe allrs2268578
SNP Nexus

SNPshotrs2268578
SNPdbers2268578
MSV3drs2268578
GWAS Ctlgrs2268578
GMAF0.3104
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs2268578 is a SNP in the lumican LUM gene.

Two populations of patients with breast cancer, comprising ~800 cases from the Mayo Clinic and ~4,500 cases from East Anglia, England, were analyzed for SNP associations in the decorin and lumican genes. rs2268578 was associated with breast cancer in both populations; in combined analyses, the odds ratio for rs2268578(C;T) was 1.1 (CI: 0.9-1.2) and 1.9 (CI: 1.3-2.8, p 2 df = 0.001) for homozygotes. [PMID 19036156OA-icon.png]


[PMID 19843670OA-icon.png] Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer

[PMID 20360993OA-icon.png] Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness.