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rs2269475

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.8 increased rheumatoid arthritis risk
(A;G) increased rheumatoid arthritis risk
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome6
Position31616154
GeneAIF1
is asnp
is mentioned by
dbSNPrs2269475
ebirs2269475
HLIrs2269475
Exacrs2269475
Varsomers2269475
Maprs2269475
PheGenIrs2269475
hapmaprs2269475
1000 genomesrs2269475
hgdprs2269475
ensemblrs2269475
gopubmedrs2269475
geneviewrs2269475
scholarrs2269475
googlers2269475
pharmgkbrs2269475
gwascentralrs2269475
openSNPrs2269475
23andMers2269475
23andMe allrs2269475
SNP Nexus

SNPshotrs2269475
SNPdbers2269475
MSV3drs2269475
GWAS Ctlgrs2269475
GMAF0.1602
Max Magnitude1.8
? (A;A) (A;G) (G;G) 28
rs2269475 is a SNP in the allograft inflammatory factor-1 (AIF-1) gene, which may be involved in inflammatory processes.

In a study of 276 Polish Caucasian patients with rheumatoid arthritis, the frequency of rs2269475(A) carriers among patients was 31.9% vs 19.1% among controls (p = 0.0003). The frequency of individuals positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies was also significantly elevated in these carriers (odds ratio 8.82, CI: 2.06-37.7).[PMID 18721278]

[PMID 17498268] Allograft inflammatory factor-1 and tumor necrosis factor single nucleotide polymorphisms in systemic sclerosis.

[PMID 17522098] An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.


[PMID 23777936] Influence of Cyclooxygenase-2 (COX-2) gene promoter-1195 and allograft inflammatory factor-1 (AIF-1) polymorphisms on allograft outcome in Hispanic kidney transplant recipients.