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rs2270954

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 Possible increased susceptibility to schizophrenia
Make rs2270954(A;C)
Make rs2270954(C;C)
ReferenceGRCh38 38.1/141
Chromosome18
Position53530928
GeneDCC
is asnp
is mentioned by
dbSNPrs2270954
ebirs2270954
HLIrs2270954
Exacrs2270954
Varsomers2270954
Maprs2270954
PheGenIrs2270954
hapmaprs2270954
1000 genomesrs2270954
hgdprs2270954
ensemblrs2270954
gopubmedrs2270954
geneviewrs2270954
scholarrs2270954
googlers2270954
pharmgkbrs2270954
gwascentralrs2270954
openSNPrs2270954
23andMers2270954
23andMe allrs2270954
SNP Nexus

SNPshotrs2270954
SNPdbers2270954
MSV3drs2270954
GWAS Ctlgrs2270954
GMAF0.1671
Max Magnitude2
? (A;A) (A;C) (C;C) 28

[PMID 22418395] Association between schizophrenia and genetic variation in DCC: A case-control study

The PMID above is interesting. It found an association between rs2270954 and schizophrenia. Patients were most likely to be homozygous for the minor allele. The study suggests that the DCC gene may contribute to individual genetic differences in susceptibility to schizophrenia. This SNP is located within the 3' untranslated region, an area known to contain a number of regulatory sequences that determine the stability and translation efficacy of mRNA.