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rs2272382

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) slightly higher body mass index
(A;G) slightly higher body mass index
(G;G) 0 common/normal
ReferenceGRCh38 38.1/141
Chromosome11
Position8089993
GeneTUB
is asnp
is mentioned by
dbSNPrs2272382
ebirs2272382
HLIrs2272382
Exacrs2272382
Varsomers2272382
Maprs2272382
PheGenIrs2272382
hapmaprs2272382
1000 genomesrs2272382
hgdprs2272382
ensemblrs2272382
gopubmedrs2272382
geneviewrs2272382
scholarrs2272382
googlers2272382
pharmgkbrs2272382
gwascentralrs2272382
openSNPrs2272382
23andMers2272382
23andMe allrs2272382
SNP Nexus

SNPshotrs2272382
SNPdbers2272382
MSV3drs2272382
GWAS Ctlgrs2272382
GMAF0.3687
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs2272382, a SNP in the TUB gene, was found in a study of 492 unrelated type-2 diabetes patients to have a significant effect on body mass index and thus obesity (1.3 kg/m(2), p= 0.016). When two populations were combined, totaling ~1200 patients, the risk allele (rs2272382(A) averaged an increase of 0.35 (–0.14 to 0.83).[PMID 16443771]

A follow-up study of 1,680 middle-aged Dutch women found that compared with non-carriers, both rs2272382(A;G) heterozygotes and (A;A) homozygotes derived less energy from fat ((A;G): -0.55+/-0.28%, p=0.05; (A;A): -0.95+/-0.48%, p=0.047). However, both genotypes were associated with an increased energy intake from carbohydrates (0.69+/-0.33%, p= 0.04 and 1.68+/-0.56%, p= 0.003, respectively), mainly because of a higher consumption of mono- and disaccharides. Both this SNP, rs2272382, as well as a linked SNP, rs1528133, were also associated with a higher glycemic load in the diet. The glycemic load was higher among those with rs2272382(A;G) and (A;A) genotypes than among (G;G) homozygotes (+1.49, CI: -0.27-3.24, and +3.89, CI: 0.94-6.85 units, respectively).[PMID 18183286OA-icon.png]


[PMID 17955208] TUB is a candidate gene for late-onset obesity in women.


[PMID 19759915OA-icon.png] Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans.