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rs2279343

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in clinvar
Make rs2279343(A;G)
Make rs2279343(G;G)
ReferenceGRCh38 38.1/141
Chromosome19
Position41009358
GeneCYP2B6
is asnp
is mentioned by
dbSNPrs2279343
ebirs2279343
HLIrs2279343
Exacrs2279343
Varsomers2279343
Maprs2279343
PheGenIrs2279343
hapmaprs2279343
1000 genomesrs2279343
hgdprs2279343
ensemblrs2279343
gopubmedrs2279343
geneviewrs2279343
scholarrs2279343
googlers2279343
pharmgkbrs2279343
gwascentralrs2279343
openSNPrs2279343
23andMers2279343
23andMe allrs2279343
SNP Nexus

SNPshotrs2279343
SNPdbers2279343
MSV3drs2279343
GWAS Ctlgrs2279343
Max Magnitude0
rs2279343, also known as Lys262Arg, is a SNP within the CYP2B6 gene.

[PMID 12642465] variants including the Arg allele include CYP2B6*4, CYP2B6*6, and CYP2B6*7





[PMID 21790905OA-icon.png] CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction


[PMID 21886015] Cytochrome P450 CYP2B6 genotypes and haplotypes in a Colombian population: identification of novel variant CYP2B6 alleles

[PMID 18728241OA-icon.png] Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation.

[PMID 19076156OA-icon.png] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.

[PMID 19239339OA-icon.png] Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.

[PMID 19659438OA-icon.png] CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.

[PMID 20459744OA-icon.png] Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.

[PMID 21694616] CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer.


[PMID 23249875] Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study


[PMID 24260284OA-icon.png] CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes


[PMID 23104099OA-icon.png] Multiple genetic variants predict steady-state nevirapine clearance in HIV-infected Cambodians.


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.


ClinVar
Risk rs2279343(G;G)
Alt rs2279343(G;G)
Reference rs2279343(A;A)
Significance Drug-response
Disease Efavirenz response efavirenz response - Metabolism/PK
Variation info
Gene CYP2B6
CLNDBN Efavirenz response efavirenz response - Metabolism/PK
Reversed 0
HGVS NC_000019.9:g.41515263A>G
CLNSRC OMIM Allelic Variant PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000106294.2, RCV000211381.1,



[PMID 25428516] Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer