Rs2294008
| is a | snp |
| is | mentioned by |
| dbSNP | rs2294008 |
| nextbio | rs2294008 |
| hapmap | rs2294008 |
| 1000 genomes | rs2294008 |
| hgdp | rs2294008 |
| ensembl | rs2294008 |
| gopubmed | rs2294008 |
| scholar | rs2294008 |
| rs2294008 | |
| pharmgkb | rs2294008 |
| gwascentral | rs2294008 |
| openSNP | rs2294008 |
| 23andMe | rs2294008 |
| 23andMe all | rs2294008 |
| SNP Nexus | |
| SNPshot | rs2294008 |
| SNPdbe | rs2294008 |
| MSV3d | rs2294008 |
| Gene | PSCA |
| Chromosome | 8 |
| Orientation | plus |
| Position | 143761931 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 2.1 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | |
| (T;T) | 2.1 | increased risk of gastric and bladder cancer |
| Make rs2294008(C;T) |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 18488030] rs2976392 and diffuse-type gastric cancer (allele-specific odds ratio (OR) = 1.62, 95% CI = 1.38-1.89, P = 1.11 x 10(-9)). Substitution of the C allele with the risk allele T at a SNP in the first exon (rs2294008, which has r(2) = 0.995, D' = 0.999 with rs2976392) reduces transcriptional activity of an upstream fragment of the gene
| GWAS snp | |
|---|---|
| PMID | [PMID 19648920] |
| Trait | Bladder cancer |
| Title | Genetic variation in the prostate stem cell antigen gene
PSCA confers susceptibility to urinary bladder cancer |
| Risk Allele | T |
| P-val | 2E-10 |
| Odds Ratio | 1.15 [1.10-1.20] |
[PMID 20083643] Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population
[PMID 20131315] Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-gastric cancer in a Chinese population
[PMID 21064099] Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population
[PMID 21070779] A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer Short title: MUC1is a gastric cancer susceptibility gene
[PMID 21070776] An association between a variation in the PSCA gene and upper gastrointestinal cancer in Caucasians
| GWAS snp | |
|---|---|
| PMID | [PMID 20972438] |
| Trait | |
| Title | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| Risk Allele | T |
| P-val | 4E-11 |
| Odds Ratio | 1.1300 [1.09-1.17] |
[PMID 21268123] Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese
[PMID 21681742] Prostate stem cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: Results from the EPIC-EURGAST Study
[PMID 22416122] Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk
[PMID 22481254] The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis
