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rs2296336

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 2.9x risk of type-1 diabetes
(C;G) 1.3x risk of type-1 diabetes
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome6
Position33668883
GeneITPR3
is asnp
is mentioned by
dbSNPrs2296336
ebirs2296336
HLIrs2296336
Exacrs2296336
Varsomers2296336
Maprs2296336
PheGenIrs2296336
hapmaprs2296336
1000 genomesrs2296336
hgdprs2296336
ensemblrs2296336
gopubmedrs2296336
geneviewrs2296336
scholarrs2296336
googlers2296336
pharmgkbrs2296336
gwascentralrs2296336
openSNPrs2296336
23andMers2296336
23andMe allrs2296336
SNP Nexus

SNPshotrs2296336
SNPdbers2296336
MSV3drs2296336
GWAS Ctlgrs2296336
GMAF0.2943
Max Magnitude0
? (C;C) (C;G) (G;G) 28
rs2296336 has been reported in a Swedish study to be associated with type-1 diabetes.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.3 (CI 1.00-1.69), and for homozygotes, 2.9 (CI 1.88-4.59). [PMID 16960798OA-icon.png]

[PMID 18340361] suggests this SNP does not play a direct role in type-1 diabetes, and was only seen in the previous study due to being in linkage disequilibrium with specific alleles of the HLA DQB1 gene.


[PMID 19143813OA-icon.png] Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.