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rs2302685

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0 common in complete genomics
Make rs2302685(C;C)
Make rs2302685(C;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position12148964
GeneLRP6
is asnp
is mentioned by
dbSNPrs2302685
ebirs2302685
HLIrs2302685
Exacrs2302685
Varsomers2302685
Maprs2302685
PheGenIrs2302685
hapmaprs2302685
1000 genomesrs2302685
hgdprs2302685
ensemblrs2302685
gopubmedrs2302685
geneviewrs2302685
scholarrs2302685
googlers2302685
pharmgkbrs2302685
gwascentralrs2302685
openSNPrs2302685
23andMers2302685
23andMe allrs2302685
SNP Nexus

SNPshotrs2302685
SNPdbers2302685
MSV3drs2302685
GWAS Ctlgrs2302685
GMAF0.1212
Max Magnitude0
? (C;C) (C;T) (T;T) 28

rs2302685 increases susceptibility to Alzheimer's disease, late-onset 1.30 times for carriers of the T allele [PMID 17517621OA-icon.png]


[PMID 22393312OA-icon.png] Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease


[PMID 18340469OA-icon.png] Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.


[PMID 19667113OA-icon.png] A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.


[PMID 20057906OA-icon.png] Mutational screening of 10 genes in Chinese patients with microphthalmia and/or coloboma.


[PMID 20926594] Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.


GET Evidence
LRP6-V1062I
aa_change Val1062Ile
aa_change_short V1062I
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.84235
summary



[PMID 24906453OA-icon.png] The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction