| Geno
|
Mag
|
Summary
|
| (T;T)
|
1.5
|
higher risk for chordoma reported in one study; no association seen in another study
|
A small study (40 patients) reported in 2012 that rs2305089(T), also knownn as Gly177Asp, was associated with chordoma development, reporting an odds ratio of 6.1 (CI: 3.1-12.1, p = 4.4 × 10e-9).{PMID|23064415}}
However, a 2013 study of 65 skull-base chordoma cases among Chinese patients found no association with rs2305089.[PMID 24232574
]
[PMID 26435504] T gene isoform expression pattern is significantly different between chordomas and notochords
[PMID 27663388] Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival.
]
