|(C;T)||2||3.5x increase in risk of asthma for Han Chinese|
|(T;T)||2||if 4 years old or younger, ~3x increased asthma risk if exposed to smoke|
A total of 651 French patients with asthma, from among 1,621 subjects in 388 families, were analyzed for SNPs in the (17q21) region. An association was found between this SNP and early-onset asthma (but not with later onset asthma) which was significant after correction at p < 0.001. Upon further study, this association was seen primarily only in children exposed to tobacco smoke. The odds ratio was 2.77, based on the most likely assumption that this risk is associated only with the recessive homozygous state (and not the heterozygous state, which is still possible). [PMID 18923164]
|Title||Genome-wide association identifies multiple ulcerative colitis susceptibility loci|
|Odds Ratio||1.15 [NR]|
|Title||A large-scale, consortium-based genomewide association study of asthma|
|Odds Ratio||1.18 [1.11-1.23]|
[PMID 22469062] Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma-like symptoms: Epidemiology and Genetics
[PMID 22370936] Genetic variants on 17q21 are associated with asthma in a Han Chinese population
[PMID 19458352] Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 21506939] Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23154084] Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes
[PMID 23028483] Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|Trait||Asthma (childhood, severe)|
|Title||A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.|
|Odds Ratio||1.32 [1.23-1.39]|
[PMID 26493291] Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population
[PMID 27163155] Polymorphisms and Haplotypes of the Chromosome Locus 17q12-17q21.1 Contribute to Adult Asthma Susceptibility in Slovenian Patients.