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rs234706(A;A)

From SNPedia

0.50 reduced risk of cleft lip / palate, 0.51 reduced risk of non-Hodgkin lymphoma. Increased responsiveness to homocysteine-lowering effects of folic acid.
Is agenotype
ofrs234706
GeneCBS
Chromosome21
Position43,065,240
mentionedby
Magnitude2.5
ReputeGood
Geno Mag Summary
(A;A) 2.5 0.50 reduced risk of cleft lip / palate, 0.51 reduced risk of non-Hodgkin lymphoma. Increased responsiveness to homocysteine-lowering effects of folic acid.
(A;G) 1.1 0.94 reduced risk of cleft lip / palate
(G;G) 0 common in clinvar

We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0.94 with one copy of the T allele (95% CI 0.63-1.4) and 0.50 (95% CI 0.26-0.96) with two copies (P = 0.008).

[PMID 18203168]

A significantly reduced risk of NHL was associated with the homozygous TT genotype in CBS (rs234706, Ex9+33C>T) (OR = 0.51, 95 % CI 0.31-0.84)

[PMID 23913011]