Have questions? Visit https://www.reddit.com/r/SNPedia

rs237025

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in clinvar
(C;T) 0
(T;T) 0.5 no credible risk
ReferenceGRCh38 38.1/141
Chromosome6
Position149400554
GeneSUMO4, TAB2
is asnp
is mentioned by
dbSNPrs237025
ebirs237025
HLIrs237025
Exacrs237025
Varsomers237025
Maprs237025
PheGenIrs237025
hapmaprs237025
1000 genomesrs237025
hgdprs237025
ensemblrs237025
gopubmedrs237025
geneviewrs237025
scholarrs237025
googlers237025
pharmgkbrs237025
gwascentralrs237025
openSNPrs237025
23andMers237025
23andMe allrs237025
SNP Nexus

SNPshotrs237025
SNPdbers237025
MSV3drs237025
GWAS Ctlgrs237025
GMAF0.3714
Max Magnitude0.5
? (C;C) (C;T) (T;T) 28
[PMID 17374705] suggested the contribution of rs237025 to type-1 diabetes, however in [PMID 19956095OA-icon.png] this failed to replicate.

This SNP is also known as Met55Val, M55V, or A163G.

This was the first SNP in SNPedia.

OMIM608829
Desc
Variant0001
Relatedalso


ClinVar
Risk rs237025(T;T)
Alt rs237025(T;T)
Reference rs237025(C;C)
Significance Other
Disease Diabetes mellitus
Variation info
Gene TAB2 SUMO4
CLNDBN Diabetes mellitus, insulin-dependent, 5
Reversed 1
HGVS NC_000006.11:g.149721690G>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000002143.1,



[PMID 16159953] The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis.

[PMID 16380915OA-icon.png] Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

[PMID 16735488] Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.

[PMID 17229939] SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.

[PMID 18330586] Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris.

[PMID 18466472OA-icon.png] Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

[PMID 18466513OA-icon.png] Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.

[PMID 18466531OA-icon.png] Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.

[PMID 18466554OA-icon.png] Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests.

[PMID 18466563OA-icon.png] Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests.

[PMID 18560894OA-icon.png] Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population.

[PMID 19122825OA-icon.png] Small ubiquitin-like modifier 4 (SUMO4) polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population.

[PMID 19956101OA-icon.png] Overview of the Rapid Response data.

[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.


GET Evidence
SUMO4-V55M
aa_change Val55Met
aa_change_short V55M
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.562093
summary



[PMID 23042402] [Association between SUMO4 polymorphisms and coronary artery disease with and without type 2 diabetes mellitus]


[PMID 25901130OA-icon.png] Genetic polymorphisms of NFκB1 -94 del/ins ATTG, NFκB1A 2758 A>G and SUMO rs237025 G>A in psoriasis


[PMID 27899942] Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes.