Rs2420946
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs2420946 |
| hapmap | rs2420946 |
| hgdp | rs2420946 |
| ensembl | rs2420946 |
| gopubmed | rs2420946 |
| scholar | rs2420946 |
| rs2420946 | |
| pharmgkb | rs2420946 |
| hgvbaseg2p | rs2420946 |
| medrefsnp | rs2420946 |
| 23andMe | rs2420946 |
| SNP Nexus |
| Gene | FGFR2 |
| Chromosome | 10 |
| Orientation | plus |
| Position | 123341313 |
| Genotype | Effect |
|---|---|
| rs2420946(T;T) | 1.64x risk for breast cancer |
| rs2420946(C;T) | 1.20x risk for breast cancer |
| rs2420946(C;C) | common |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs2420946(C;C) | 00 | common |
| Rs2420946(C;T) | 1.20x risk for breast cancer | |
| Rs2420946(T;T) | 1.64x risk for breast cancer |
This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. [PMID 17529973]
[PMID 18845558] Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs (rs2981582, rs1219648 and rs2420946) were at 1.36x increased risk for breast cancer (CI: 1.13-1.62, p = 0.001).
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
| Neighbor | rs2981582 |
| Distance | 993 |
