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rs2420946

来自SNPedia
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Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common
(C;T) 2 1.20x risk for breast cancer
(T;T) 2.1 1.64x risk for breast cancer
ReferenceGRCh38 38.1/142
Chromosome10
Position121591810
GeneFGFR2
is asnp
is mentioned by
dbSNPrs2420946
ebirs2420946
HLIrs2420946
Exacrs2420946
Varsomers2420946
Maprs2420946
PheGenIrs2420946
hapmaprs2420946
1000 genomesrs2420946
hgdprs2420946
ensemblrs2420946
gopubmedrs2420946
geneviewrs2420946
scholarrs2420946
googlers2420946
pharmgkbrs2420946
gwascentralrs2420946
openSNPrs2420946
23andMers2420946
23andMe allrs2420946
SNP Nexus

SNPshotrs2420946
SNPdbers2420946
MSV3drs2420946
GWAS Ctlgrs2420946
GMAF0.4362
Max Magnitude2.1
? (C;C) (C;T) (T;T) 28

This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. [PMID 17529973OA-icon.png]

[PMID 18845558] Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs (rs2981582, rs1219648 and rs2420946) were at 1.36x increased risk for breast cancer (CI: 1.13-1.62, p = 0.001).

Neighborrs2981582
Distance993


[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies


[PMID 18285324OA-icon.png] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.


[PMID 18326623OA-icon.png] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.


[PMID 19223389OA-icon.png] FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.


[PMID 19497954OA-icon.png] Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.


[PMID 19500394OA-icon.png] Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.


[PMID 19582883] FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 20300826] Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis.


[PMID 20364400] Quantitative assessment of the effect of FGFR2 gene polymorphism on the risk of breast cancer.


[PMID 20554749OA-icon.png] FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.


[PMID 23225170] Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population


[PMID 24454457OA-icon.png] Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women


[PMID 23184080] Assessing interactions between the associations of fibroblast growth factor receptor 2 common genetic variants and hormone receptor status with breast cancer risk.