rs2420946
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common |
| (C;T) | 2 | 1.20x risk for breast cancer |
| (T;T) | 2.1 | 1.64x risk for breast cancer |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 121591810 |
| Gene | FGFR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2420946 |
| dbSNP (classic) | rs2420946 |
| ClinGen | rs2420946 |
| ebi | rs2420946 |
| HLI | rs2420946 |
| Exac | rs2420946 |
| Gnomad | rs2420946 |
| Varsome | rs2420946 |
| LitVar | rs2420946 |
| Map | rs2420946 |
| PheGenI | rs2420946 |
| Biobank | rs2420946 |
| 1000 genomes | rs2420946 |
| hgdp | rs2420946 |
| ensembl | rs2420946 |
| geneview | rs2420946 |
| scholar | rs2420946 |
| rs2420946 | |
| pharmgkb | rs2420946 |
| gwascentral | rs2420946 |
| openSNP | rs2420946 |
| 23andMe | rs2420946 |
| SNPshot | rs2420946 |
| SNPdbe | rs2420946 |
| MSV3d | rs2420946 |
| GWAS Ctlg | rs2420946 |
| GMAF | 0.4362 |
| Max Magnitude | 2.1 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. [PMID 17529973
]
[PMID 18845558] Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs (rs2981582, rs1219648 and rs2420946) were at 1.36x increased risk for breast cancer (CI: 1.13-1.62, p = 0.001).
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 18285324] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.
[PMID 18326623] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
[PMID 19223389] FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
[PMID 19497954] Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.
[PMID 19500394] Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
[PMID 19582883] FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 20300826] Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis.
[PMID 20364400] Quantitative assessment of the effect of FGFR2 gene polymorphism on the risk of breast cancer.
[PMID 20554749] FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.
[PMID 23225170] Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population
[PMID 24454457] Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women
[PMID 23184080] Assessing interactions between the associations of fibroblast growth factor receptor 2 common genetic variants and hormone receptor status with breast cancer risk.
