|?|| (C;C) (C;T) (T;T) ||28|
is a SNP on chromosome 5.
A case control study of ~2,000 women found that each rs244715(T) allele was associated with an average increase in age at menopause of ~1 month. This also meant that each rs244715(C) allele yielded an odds ratio of 1.2 (CI: 1.09–1.32, p = 1.7 x 10e-4) of early menopause, defined as occurring before the age of 46.[PMID 20952801]
Overall, women homozygous for the "early" alleles at all 4 SNPs found in this study were ~4 times more likely to undergo menopause early compared to women who had a total of 3 or less risk alleles. However, the ability to predict which women will actually undergo early menopause using these 4 SNPs is still low.[PMID 20952801]