Have questions? Visit https://www.reddit.com/r/SNPedia

rs2472297

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common on affy axiom data
(C;T) 1.2 Associated with (slightly) increased coffee consumption
(T;T) 1.2 Associated with (slightly) increased coffee consumption
ReferenceGRCh38 38.1/141
Chromosome15
Position74735539
is asnp
is mentioned by
dbSNPrs2472297
ebirs2472297
HLIrs2472297
Exacrs2472297
Varsomers2472297
Maprs2472297
PheGenIrs2472297
hapmaprs2472297
1000 genomesrs2472297
hgdprs2472297
ensemblrs2472297
gopubmedrs2472297
geneviewrs2472297
scholarrs2472297
googlers2472297
pharmgkbrs2472297
gwascentralrs2472297
openSNPrs2472297
23andMers2472297
23andMe allrs2472297
SNP Nexus

SNPshotrs2472297
SNPdbers2472297
MSV3drs2472297
GWAS Ctlgrs2472297
GMAF0.1001
Max Magnitude1.2
rs2472297 is a SNP located between the CYP1A1 and CYP1A2 genes on ch 15q24.

A meta-analysis of four GWAS studies of coffee consumption among a total of ~8,000 coffee drinkers of European ancestry found that the rs2472297(T) was strongly associated with increased consumption (p = 5.4 x 10e-14). The estimated effect was an increase of 0.2 cups a day per allele for both this SNP and one other (rs6968865).[PMID 21357676OA-icon.png]

? (C;C) (C;T) (T;T) 28
[PMID 25288136OA-icon.png] Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

[PMID 19479063OA-icon.png] Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.


[PMID 20018080OA-icon.png] Effects of covariates and interactions on a genome-wide association analysis of rheumatoid arthritis.


[PMID 21876539OA-icon.png] Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.


[PMID 22854411] Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption


[PMID 23492908] Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure