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rs2499846

From SNPedia

Orientationminus
Stabilizedminus
Make rs2499846(C;C)
Make rs2499846(C;T)
Make rs2499846(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position161963258
GeneATF6
is asnp
is mentioned by
dbSNPrs2499846
ebirs2499846
HLIrs2499846
Exacrs2499846
Varsomers2499846
Maprs2499846
PheGenIrs2499846
hapmaprs2499846
1000 genomesrs2499846
hgdprs2499846
ensemblrs2499846
gopubmedrs2499846
geneviewrs2499846
scholarrs2499846
googlers2499846
pharmgkbrs2499846
gwascentralrs2499846
openSNPrs2499846
23andMers2499846
23andMe allrs2499846
SNP Nexus

SNPshotrs2499846
SNPdbers2499846
MSV3drs2499846
GWAS Ctlgrs2499846
GMAF0.3981
Max Magnitude
? (C;C) (C;T) (T;T) 28
This SNP was identified as a "core" SNP helping to define one (of nine total) runs of homozygosity (ROH) potentially associated with increased risk for schizophrenia. Each region consists of at least 100 consecutive SNPs, generally spanning 500KB or more, for which both chromosomes in an individual were homozygous. The overall odds ratio for schizophrenia associated with inheriting 1, 2, or 3 of these 9 ROHs was calculated to be 3.3, 5.4, or 24, respectively, with 95% confidence intervals of (1.9-5.7), (3.7-16.1), and (6.9-83.9), respectively.[PMID 18077426OA-icon.png]

This particular SNP, rs2499846, was deemed to be the core SNP of a region on chromosome 1 with 173 SNPs spanning 574KB from 1:158440777 to 1:159015569 (build 35). Potentially independent of the ROH, the risk allele for this SNP in the orientation as displayed in HapMap v21a is (T).[PMID 18077426OA-icon.png]