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rs2569190

From SNPedia

Orientationplus
Stabilizedplus
Make rs2569190(A;A)
Make rs2569190(A;G)
Make rs2569190(G;G)
ReferenceGRCh38 38.1/141
Chromosome5
Position140633331
GeneCD14
is asnp
is mentioned by
dbSNPrs2569190
ebirs2569190
HLIrs2569190
Exacrs2569190
Varsomers2569190
Maprs2569190
PheGenIrs2569190
hapmaprs2569190
1000 genomesrs2569190
hgdprs2569190
ensemblrs2569190
gopubmedrs2569190
geneviewrs2569190
scholarrs2569190
googlers2569190
pharmgkbrs2569190
gwascentralrs2569190
openSNPrs2569190
23andMers2569190
23andMe allrs2569190
SNP Nexus

SNPshotrs2569190
SNPdbers2569190
MSV3drs2569190
GWAS Ctlgrs2569190
GMAF0.4734
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs2569190, also known as C260T, is a SNP in the CD14 gene.

[PMID 18727828OA-icon.png] rs2569190(C) (frequency = 39%) increased stroke risk among smokers (OR = 2.05, 95% CI=1.09-3.86, p=0.03), but not among non-smokers (OR = 0.93, 95% CI=0.62-1.39, p=0.72)

[PMID 18417506] rs1295685 and rs20541 were significantly associated with elevated IgE levels in pooled analyses. rs2569190(T;T) and rs2569191(C;C) genotypes associated with lower IgE

A meta-analysis of 7 studies (comprising a total of 1488 patients and 1600 control subjects) found no significant association between rs2569190 and cerebrovascular diseases.[PMID 19433913]

Neighborrs5744455
Distance391
[PMID 19468702OA-icon.png] Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity


[PMID 19701968OA-icon.png] Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation

[PMID 19830784OA-icon.png] Association of CD14 variant with prostate cancer in African American men


[PMID 19968655] The role of lipopolysaccharide in the development of atopy in humans


[PMID 20109750] Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli


[PMID 22015088] CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 15867866] Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children.


[PMID 16614348] Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment.


[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).


[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 16846490OA-icon.png] Lemierre's syndrome and genetic polymorphisms: a case report.


[PMID 17062130OA-icon.png] Polymorphisms within inflammatory genes and colorectal cancer.


[PMID 18987746OA-icon.png] Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19337058OA-icon.png] CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19759553OA-icon.png] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.


[PMID 20398919] CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?


[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.


[PMID 21320344OA-icon.png] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.


[PMID 21333644] C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the Tunisian population.


[PMID 21389010] Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction.


[PMID 21596674OA-icon.png] Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.


[PMID 21885391] Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.


[PMID 21996339] Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.


[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.


[PMID 22494793] Innate immunity gene single nucleotide polymorphisms and otitis media


[PMID 23741383OA-icon.png] CD14 -159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis


[PMID 23349936OA-icon.png] Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity


[PMID 24028589] TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk


[PMID 22749237OA-icon.png] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.


[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 25394369OA-icon.png] The Association of Polymorphisms of TLR4 and CD14 Genes with Susceptibility to Sepsis in a Chinese Population


[PMID 25000179OA-icon.png] Genetic polymorphisms and sepsis in premature neonates


[PMID 25840711OA-icon.png] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis


[PMID 26174031] TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis


[PMID 26462562OA-icon.png] Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout


[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease


[PMID 27277665] Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population.