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rs2651899

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;G) 1.1 1.1x higher risk for migraines
(G;G) 1.2 1.2x higher risk for migraines


Make rs2651899(A;A)
ReferenceGRCh38 38.1/141
Chromosome1
Position3167148
GenePRDM16
is asnp
is mentioned by
dbSNPrs2651899
ebirs2651899
HLIrs2651899
Exacrs2651899
Varsomers2651899
Maprs2651899
PheGenIrs2651899
hapmaprs2651899
1000 genomesrs2651899
hgdprs2651899
ensemblrs2651899
gopubmedrs2651899
geneviewrs2651899
scholarrs2651899
googlers2651899
pharmgkbrs2651899
gwascentralrs2651899
openSNPrs2651899
23andMers2651899
23andMe allrs2651899
SNP Nexus

SNPshotrs2651899
SNPdbers2651899
MSV3drs2651899
GWAS Ctlgrs2651899
GMAF0.4995
Max Magnitude1.2
? (A;A) (A;G) (G;G) 28
rs2651899 is a SNP on ch 1p36.32 in the PRDM16 gene.

A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk increases on its own. The odds ratio for the slightly rarer rs2651899(G) allele was 1.11 (CI: 1.07 - 1.15, p = 3.8 x 10e-9).10.1038/ng.856

A 2013 study published by the American Headache Society reports significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the Northern Indian population. [PMID 24266335]

GWAS snp
PMID [PMID 21666692OA-icon.png]
Trait
Title Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Risk Allele C
P-val 4E-9
Odds Ratio 1.1100 [1.07-1.15]


[PMID 22072275OA-icon.png] Genetics of migraine in the age of genome-wide association studies


[PMID 24021092] PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients


[PMID 23294458] Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

GWAS snp
PMID [PMID 23793025OA-icon.png]
Trait Migraine
Title Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Risk Allele C
P-val 4E-14
Odds Ratio 1.09 [1.07-1.11]

[PMID 24266335] Genome-wide-associated variants in migraine susceptibility: a replication study from North India.


[PMID 24674449OA-icon.png] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample