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rs2665390

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.4 1.4x increased risk for ovarian cancer
(C;T) 1.2 1.2x increased risk for ovarian cancer
(T;T) 0 common in complete genomics
ReferenceGRCh38 38.1/141
Chromosome3
Position156679960
GeneLOC102724343, TIPARP
is asnp
is mentioned by
dbSNPrs2665390
ebirs2665390
HLIrs2665390
Exacrs2665390
Varsomers2665390
Maprs2665390
PheGenIrs2665390
hapmaprs2665390
1000 genomesrs2665390
hgdprs2665390
ensemblrs2665390
gopubmedrs2665390
geneviewrs2665390
scholarrs2665390
googlers2665390
pharmgkbrs2665390
gwascentralrs2665390
openSNPrs2665390
23andMers2665390
23andMe allrs2665390
SNP Nexus

SNPshotrs2665390
SNPdbers2665390
MSV3drs2665390
GWAS Ctlgrs2665390
GMAF0.06061
Max Magnitude1.4
? (C;C) (C;T) (T;T) 28
rs2665390 is a SNP in chromosomal region 3q25, in the TCDD-inducible poly(ADP-ribose) polymerase TIPARP gene.

A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 7.1 × 10e-8) evidence for slightly elevated risk associated with the rs2665390(C) allele, with an odds ratio of 1.24 (CI: 1.15–1.34) as calculated for the serous subtype (of ovarian cancer).[PMID 20852632OA-icon.png]


[PMID 22235027OA-icon.png] Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.


[PMID 22253144OA-icon.png] Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.

GWAS snp
PMID [PMID 23544013OA-icon.png]
Trait Ovarian cancer in BRCA1 mutation carriers
Title Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
Risk Allele C
P-val 7E-6
Odds Ratio 1.46 [1.25-1.71]


[PMID 23133607OA-icon.png] Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.


[PMID 25173882OA-icon.png] Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population