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rs27072

From SNPedia

Associated with increased susceptibility to alcohol withdrawal symptoms and ADHD.
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD.
(C;T) 1.9 Lower risk of alcohol withdrawal seizures, and perhaps lower odds of ADHD.
(T;T) 1.9 Lower risk of alcohol withdrawal seizures, and probably lower odds of ADHD.
ReferenceGRCh38 38.1/141
Chromosome5
Position1394407
GeneSLC6A3
is asnp
is mentioned by
dbSNPrs27072
ebirs27072
HLIrs27072
Exacrs27072
Varsomers27072
Maprs27072
PheGenIrs27072
hapmaprs27072
1000 genomesrs27072
hgdprs27072
ensemblrs27072
gopubmedrs27072
geneviewrs27072
scholarrs27072
googlers27072
pharmgkbrs27072
gwascentralrs27072
openSNPrs27072
23andMers27072
23andMe allrs27072
SNP Nexus

SNPshotrs27072
SNPdbers27072
MSV3drs27072
GWAS Ctlgrs27072
GMAF0.1919
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs27072, a SNP in the dopamine transporter SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor, rs27048. The rs27072 polymorphism has been shown to be significantly associated with ADHD in clinical samples of Canadian children aged 6 to 16 [Feng et al., 2005] and the significant association was also reported by Ouellet-Morin et al. in a Canadian twin study, 2008 (Am. J. of Medical Genetics Part B, 147B:1442-1449 (2008). [PMID 18070248]
OMIM143465
DescATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
Variant
Relatedalso
OMIM126455
DescSOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE),
Variant
Relatedalso

[PMID 19740369]The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds.

[PMID 19879111]Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese.

[PMID 21525861OA-icon.png]Dopamine Transporter Gene Variant Affecting Expression in Human Brain is Associated with Bipolar Disorder.

[PMID 16082693]Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD).

[PMID 18165969]Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins.

[PMID 19506906]Candidate gene studies of ADHD: a meta-analytic review.

[PMID 14685824] Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence.

[PMID 18690117OA-icon.png] Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers.

[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

[PMID 20505557] Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics.

[PMID 20580759] Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia.

[PMID 21354244] The role of dopamine transporter (SLC6A3) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) gene polymorphisms in personality traits.

Alcohol Dependence


[PMID 23340505OA-icon.png] Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction


[PMID 23647133OA-icon.png] The association of a novel haplotype in the dopamine transporter with preschool age posttraumatic stress disorder.


[PMID 24780147] Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder


[PMID 25683821] The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence