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rs2735839

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.8 in prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancer
(A;G) 1.6 in prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancer
(G;G) 0
ReferenceGRCh38 38.1/141
Chromosome19
Position50861367
GeneKLK3
is asnp
is mentioned by
dbSNPrs2735839
ebirs2735839
HLIrs2735839
Exacrs2735839
Varsomers2735839
Maprs2735839
PheGenIrs2735839
hapmaprs2735839
1000 genomesrs2735839
hgdprs2735839
ensemblrs2735839
gopubmedrs2735839
geneviewrs2735839
scholarrs2735839
googlers2735839
pharmgkbrs2735839
gwascentralrs2735839
openSNPrs2735839
23andMers2735839
23andMe allrs2735839
SNP Nexus

SNPshotrs2735839
SNPdbers2735839
MSV3drs2735839
GWAS Ctlgrs2735839
GMAF0.2916
Max Magnitude1.8
? (A;A) (A;G) (G;G) 28
[PMID 25274378OA-icon.png] A study of ~1,800 Caucasian prostate cancer patients concludes that the rs2735839(A) allele is associated with aggressive prostate cancer in general, and more specifically, in Gleason score 7 patients, it is more often associated with being GS 4 + 3 rather than GS 3 + 4 (odd ratio 1.85, CI: 1.31-2.61).

cancer-genetics these snps influence genetic risk for prostate cancer

[PMID 19366831OA-icon.png] Genotyping 13 SNPs (including this one) in 1,308 Caucasian prostate cancer patients led to the conclusion that while none of the SNP associations were as significant as having a first-degree family history of the disease, they did replicate. And in fact, for rs2735839, the risk estimate varied by family history.

GWAS
SNP rs2735839
PubMedID [PMID 18264097]
Condition Prostate cancer
Gene KLK3
Risk Allele G
pValue 2.00E-018
OR 1.2
95% CI 1.10-1.33


[PMID 19336566OA-icon.png] Replication of the 10q11 and Xp11 Prostate Cancer Risk Variants: Results from a Utah Pedigree-Based Study.

OMIM611959
DescPROSTATE CANCER, HEREDITARY, 15; HPC15
Variant
Relatedalso

[PMID 19902474] Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans



[PMID 20460480OA-icon.png] Susceptibility loci associated with prostate cancer progression and mortality


[PMID 21465221OA-icon.png] Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3


[PMID 22549899OA-icon.png] Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans


[PMID 18708398OA-icon.png] Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.


[PMID 18794092OA-icon.png] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.


[PMID 18974127OA-icon.png] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.


[PMID 19104501OA-icon.png] Prostate cancer genomics: towards a new understanding.


[PMID 19153072OA-icon.png] Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.


[PMID 19318432OA-icon.png] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.


[PMID 19318570OA-icon.png] A novel prostate cancer susceptibility locus at 19q13.


[PMID 19434657OA-icon.png] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.


[PMID 19505914OA-icon.png] Two independent prostate cancer risk-associated Loci at 11q13.


[PMID 19549807OA-icon.png] Prostate cancer risk associated loci in African Americans.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 19823874OA-icon.png] A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.


[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.


[PMID 20369022OA-icon.png] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.


[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.


[PMID 21318478OA-icon.png] Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.


[PMID 21367958OA-icon.png] Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.


[PMID 21538423OA-icon.png] Early onset prostate cancer has a significant genetic component.


GET Evidence
rs2735839
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.75
summary



Prostate-Specific Antigen

GWAS snp
PMID [PMID 23269536]
Trait Prostate-specific antigen levels
Title Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
Risk Allele G
P-val 6E-37
Odds Ratio .19 [NR] % higher levels


[PMID 24411283OA-icon.png] Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium


[PMID 22901566] Effectiveness of the combined evaluation of KLK3 genetics and free-to-total prostate specific antigen ratio for prostate cancer diagnosis.


[PMID 23543094OA-icon.png] Testing for associations between loci and environmental gradients using latent factor mixed models.


[PMID 25715684] Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases