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rs2811712

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 Normal (higher) risk of physical impairment with age.
(A;G) 2 1.5x less risk for physical impairment with age.
(G;G) 2.1 >1.5x less risk for physical impairment with age.
ReferenceGRCh38 38.1/141
Chromosome9
Position21998036
GeneCDKN2B-AS1
is asnp
is mentioned by
dbSNPrs2811712
ebirs2811712
HLIrs2811712
Exacrs2811712
Varsomers2811712
Maprs2811712
PheGenIrs2811712
hapmaprs2811712
1000 genomesrs2811712
hgdprs2811712
ensemblrs2811712
gopubmedrs2811712
geneviewrs2811712
scholarrs2811712
googlers2811712
pharmgkbrs2811712
gwascentralrs2811712
openSNPrs2811712
23andMers2811712
23andMe allrs2811712
SNP Nexus

SNPshotrs2811712
SNPdbers2811712
MSV3drs2811712
GWAS Ctlgrs2811712
GMAF0.1616
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28
rs2811712 is a SNP associated with physical function in older individuals, and thus indirectly associated with longevity.

In a study ultimately totaling over 3,300 elderly Caucasian individuals, the less common rs2811712(G) allele was associated with reduced physical impairment. Overall, severely limited physical function was present in 15.0% of the more common rs2811712(A;A) homozygotes, versus 7.0% of the rs2811712(G;G) homozygotes, yielding a per risk allele odds ratio of 1.48 (CI: 1.17-1.88, p=0.001).[PMID 17459456OA-icon.png]


[PMID 22621687] Heterozygote Genotypes at rs2222823 and rs2811712 SNP Loci are Associated with Cerebral Small Vessel Disease in Han Chinese Population

[PMID 18174243OA-icon.png] Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.

[PMID 18431743OA-icon.png] Consortium analysis of 7 candidate SNPs for ovarian cancer.

[PMID 19258477OA-icon.png] Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.

[PMID 19343170OA-icon.png] INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.

[PMID 20386740OA-icon.png] Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.