From SNPedia
rs2814778 is within the
DARC gene, which encodes the Duffy blood group antigen [
PMID 7663520]. This SNP shows an almost perfectly fixed difference in frequency between Europeans and those with African ancestry. [One exception appears to be a certain population of Czech gypsies, and certain non-
Ashkenazi Jewish populations.]. Additionally the Namibian San samples of the CEPH-HGDP are, uncharacteristically for Africans, all AA homozygotes for this SNP.
The rs2814778 (G) allele is associated with African populations, while rs2814778 (A) is associated with European populations and south-western Native American populations.
[PMID 19180233] rs2814778(G;G) protect against Plasmodium vivax malaria and predicts of white blood cell and neutrophil count
spittoon discussion
Related to WHITE BLOOD CELL COUNT QUANTITATIVE TRAIT LOCUS 1; WBCQ1
according to
omim 611862. See
also
Related to BLOOD GROUP--DUFFY SYSTEM; FY
according to
omim 110700. See
also
| PharmGKB | PA162168956 |
| Name | DARC: T-46C |
| Annotation | African-American individuals with the C/C genotype of this promoter SNP are 40% more likely to acquire HIV-1 than T/T or T/C individuals. However, once infected, those with the C/C genotype exhibited slower disease progression. |
| Gene | DARC, CADM3 |
| Featue | |
| Evidence | PubMed ID:18621010 |
| Drugs | |
| Diseases | Acquired Immunodeficiency Syndrome |
| Curation Level | Curated |
