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rs2820037

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;T) 1.5x risk of high blood pressure
(T;T) 1.1x risk of high blood pressure
ReferenceGRCh38 38.1/141
Chromosome1
Position239273242
is asnp
is mentioned by
dbSNPrs2820037
ebirs2820037
HLIrs2820037
Exacrs2820037
Varsomers2820037
Maprs2820037
PheGenIrs2820037
hapmaprs2820037
1000 genomesrs2820037
hgdprs2820037
ensemblrs2820037
gopubmedrs2820037
geneviewrs2820037
scholarrs2820037
googlers2820037
pharmgkbrs2820037
gwascentralrs2820037
openSNPrs2820037
23andMers2820037
23andMe allrs2820037
SNP Nexus

SNPshotrs2820037
SNPdbers2820037
MSV3drs2820037
GWAS Ctlgrs2820037
GMAF0.1809
Max Magnitude0
? (A;A) (A;T) (T;T) 28
rs2820037 has been reported in a large study to be associated with high blood pressure.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.54 (CI 1.03-2.31), and for homozygotes, 1.09 (CI 0.74-1.62). [PMID 17554300OA-icon.png]

GWAS
SNP rs2820037
PubMedID [PMID 17554300OA-icon.png]
Condition Hypertension
Gene RYR2,CHRM3,ZP4
Risk Allele T
pValue 8.00E-007
OR 1.54
95% CI 1.03-2.31



[PMID 18523456OA-icon.png] Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program.

[PMID 20018036OA-icon.png] Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.


GET Evidence
rs2820037
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.304688
summary



[PMID 23438931OA-icon.png] Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.