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rs2832407

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 topiramate may work to reduce heavy drinking best for this genotype
Make rs2832407(A;A)
Make rs2832407(A;C)
ReferenceGRCh38 38.1/141
Chromosome21
Position29595188
GeneGRIK1, GRIK1-AS2
is asnp
is mentioned by
dbSNPrs2832407
ebirs2832407
HLIrs2832407
Exacrs2832407
Varsomers2832407
Maprs2832407
PheGenIrs2832407
hapmaprs2832407
1000 genomesrs2832407
hgdprs2832407
ensemblrs2832407
gopubmedrs2832407
geneviewrs2832407
scholarrs2832407
googlers2832407
pharmgkbrs2832407
gwascentralrs2832407
openSNPrs2832407
23andMers2832407
23andMe allrs2832407
SNP Nexus

SNPshotrs2832407
SNPdbers2832407
MSV3drs2832407
GWAS Ctlgrs2832407
GMAF0.4481
Max Magnitude2

The rs2832407(C) allele has inconsistently been linked to alcoholism and its treatment. Nonetheless, a 2014 report based on 138 patients concludes that rs2832407(C;C) individuals show a greater decrease than non-carriers (of a rs2832407(C) allele) in the number of heavy drinking days per week when taking topiramate at a dose of 200 mg/daily.[PMID 24525690OA-icon.png] A follow-up study done 3 and 6 months after treatment seemed to mostly confirm the topiramate benefit preferentially to rs2832407(C;C) individuals.[PMID 25581656OA-icon.png]

? (A;A) (A;C) (C;C) 28
[PMID 19320626OA-icon.png] Association of Markers in the 3' Region of the GluR5 Kainate Receptor Subunit Gene to Alcohol Dependence.


[PMID 19331489OA-icon.png] A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers


[PMID 24525690OA-icon.png] Topiramate Treatment for Heavy Drinkers: Moderation by a GRIK1 Polymorphism